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2025, Vol: 50, Issue: 4
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Original Research 
RMJ. 2025; 50(4): 878-880


Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults

Hina Aslam, Aisha Qayyum, Imrana Maqsood, Muhammad Tahir, Iqra Athar, Amtul Hafeez.


Abstract
Objective: To determine the effect of Sodium Valproate (VPA) and Levetiracetam (LEV) monotherapy on levels of 25-OH Cholecalciferol in young epileptic Pakistani adult patients.
Methodology: This cross-sectional study included 100 healthy and epileptic individuals aged between 15-24 years, with no sex predilection. All participants were divided into four groups I-IV (n=25 each); healthy control, diseased control, epileptic patients on VPA and LEV monotherapies, respectively. Serum 25-OH Cholecalciferol was measured. Data were analyzed at SPSS version 23.0. One-way ANOVA test was used to compare all groups.
Results: Mean serum levels of 25-OH Cholecalciferol were significantly lowered (p<0.05) in epileptic adults treated with VPA and LEV monotherapy than the healthy control group.
Conclusion: Young epileptic Pakistani adults on VPA and LEV monotherapy had reduced levels of serum 25-OH cholecalciferol.

Key words: Epilepsy, Idiopathic generalized, valproic acid, levetiracetam, vitamin D.


 
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How to Cite this Article
Pubmed Style

Aslam H, Qayyum A, Maqsood I, Tahir M, Athar I, Hafeez A. Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. RMJ. 2025; 50(4): 878-880.

Web Style

Aslam H, Qayyum A, Maqsood I, Tahir M, Athar I, Hafeez A. Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. https://www.rmj.org.pk/?mno=249612 [Access: October 30, 2025].

AMA (American Medical Association) Style

Aslam H, Qayyum A, Maqsood I, Tahir M, Athar I, Hafeez A. Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. RMJ. 2025; 50(4): 878-880.


Vancouver/ICMJE Style

Aslam H, Qayyum A, Maqsood I, Tahir M, Athar I, Hafeez A. Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. RMJ. (2025), [cited October 30, 2025]; 50(4): 878-880.


Harvard Style

Aslam, H., Qayyum, . A., Maqsood, . I., Tahir, . M., Athar, . I. & Hafeez, . A. (2025) Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. RMJ, 50 (4), 878-880.


Turabian Style

Aslam, Hina, Aisha Qayyum, Imrana Maqsood, Muhammad Tahir, Iqra Athar, and Amtul Hafeez. 2025. Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. Rawal Medical Journal, 50 (4), 878-880.


Chicago Style

Aslam, Hina, Aisha Qayyum, Imrana Maqsood, Muhammad Tahir, Iqra Athar, and Amtul Hafeez. "Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults." Rawal Medical Journal 50 (2025), 878-880.


MLA (The Modern Language Association) Style

Aslam, Hina, Aisha Qayyum, Imrana Maqsood, Muhammad Tahir, Iqra Athar, and Amtul Hafeez. "Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults." Rawal Medical Journal 50.4 (2025), 878-880. Print.


APA (American Psychological Association) Style

Aslam, H., Qayyum, . A., Maqsood, . I., Tahir, . M., Athar, . I. & Hafeez, . A. (2025) Effect of sodium valproate and levetiracetam monotherapy on vitamin D levels among young epileptic Pakistani adults. Rawal Medical Journal, 50 (4), 878-880.


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