ISSN 0303-5212
 

Original Research 


Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome

Dhai Abdulalazize Rashid, Raghda Mohammed Bardan.

Abstract
Objective: To assess the efficacy of myo-inositol and metformin alone or in combination with letrozol for inducing ovulation and achieving pregnancy in anovulatory women with polycystic ovary syndrome.
Methodology: This randomized case-controlled study included 92 women with anovulatory polycystic ovarian syndrome with infertility of at least one year. They were divided into two groups; group 1 included 44 women who received metformin, inositol and letrozole and group 2 included 48 women who received metformin and inositol for 6 months. We assessed their effect on menstrual cycle, ovulation rate, pregnancy rate and serum testosterone.
Results: Both groups had significantly shorter cycles following therapy (p=0.004 and 0.003, respectively). In group 1, 32 out of 44 females ovulated, but in group 2, only 16 out of 48 females ovulated (72.7 vs. 33.3%, respectively). Pregnancy rate was similarly higher in group 1 (54.5 vs. 27.1%). After therapy, individuals in group 1 had significantly lower testosterone levels (55.16±16.33 versus 59.15±23.44; p=0.044).
Conclusion: We conclude that the combination of metformin and inositol with letrozol in patients with polycystic ovarian syndrome may generate a more positive outcome in terms of increased ovulation and pregnancy rate, restoration of menstruation and decreased hyperandrogenism.

Key words: Polycystic ovarian syndrome, ovulation induction, metformin, inositol, letrozol.


 
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How to Cite this Article
Pubmed Style

Rashid DA, Bardan RM. Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. RMJ. 2023; 48(2): 370-374. doi:10.5455/rmj.20230121104735


Web Style

Rashid DA, Bardan RM. Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. https://www.rmj.org.pk/?mno=141486 [Access: December 05, 2023]. doi:10.5455/rmj.20230121104735


AMA (American Medical Association) Style

Rashid DA, Bardan RM. Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. RMJ. 2023; 48(2): 370-374. doi:10.5455/rmj.20230121104735



Vancouver/ICMJE Style

Rashid DA, Bardan RM. Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. RMJ. (2023), [cited December 05, 2023]; 48(2): 370-374. doi:10.5455/rmj.20230121104735



Harvard Style

Rashid, D. A. & Bardan, . R. M. (2023) Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. RMJ, 48 (2), 370-374. doi:10.5455/rmj.20230121104735



Turabian Style

Rashid, Dhai Abdulalazize, and Raghda Mohammed Bardan. 2023. Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. Rawal Medical Journal, 48 (2), 370-374. doi:10.5455/rmj.20230121104735



Chicago Style

Rashid, Dhai Abdulalazize, and Raghda Mohammed Bardan. "Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome." Rawal Medical Journal 48 (2023), 370-374. doi:10.5455/rmj.20230121104735



MLA (The Modern Language Association) Style

Rashid, Dhai Abdulalazize, and Raghda Mohammed Bardan. "Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome." Rawal Medical Journal 48.2 (2023), 370-374. Print. doi:10.5455/rmj.20230121104735



APA (American Psychological Association) Style

Rashid, D. A. & Bardan, . R. M. (2023) Use of two insulin sensitizers in ovulation induction for women with polycystic ovary syndrome. Rawal Medical Journal, 48 (2), 370-374. doi:10.5455/rmj.20230121104735