ISSN 0303-5212
 

Original Research 


A comparative clinical trial of artemether and quinine in Cerebral Malaria

Sheraz Jamal Khan, Syed Munib.

Abstract
Objective: To compare artemether and quinine as treatment for cerebral malaria in hospitalized adult patients
Patients and Methods: Fifty cases of cerebral malaria who fulfilled the diagnostic criteria of WHO were placed at random into two groups of 25 patients in each group. These groups were named Group A and group B. Group A patients were treated with Quinine infusion and group B patients were treated with Artemether intramuscularly. Clinical features, temperature and laboratory detection of Falciparum were noted every twelve hours. Side effects were also noted and 12 hourly blood sugar was taken from all patients.
Results: In group A, twenty (80%) patients recovered completely and five (20%) died, while in group B, 21 (84%) patients recovered and four (16%) died. Only one patient (4%) in quinine group developed hypoglycemia at 12 hours. Mean disappearance time of Plasmodium from the blood of Group A was 36 hours and in group B, it as 24 hours. Mean time for regaining full consciousness with orientation in time space and person and no neurological deficit was 36 hours in both groups.
Conclusion: Quinine and artemether are equally effective in cerebral malaria. The side effects with Quinine seem to be negligible in this study. (Rawal Med J 2005;30:62-64).

Key words: Cerebral malaria, artemether, quinine


 
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Pubmed Style

Sheraz Jamal Khan, Syed Munib. A comparative clinical trial of artemether and quinine in Cerebral Malaria . RMJ. 2005; 30(2): 62-64.


Web Style

Sheraz Jamal Khan, Syed Munib. A comparative clinical trial of artemether and quinine in Cerebral Malaria . https://www.rmj.org.pk/?mno=8859 [Access: December 05, 2023].


AMA (American Medical Association) Style

Sheraz Jamal Khan, Syed Munib. A comparative clinical trial of artemether and quinine in Cerebral Malaria . RMJ. 2005; 30(2): 62-64.



Vancouver/ICMJE Style

Sheraz Jamal Khan, Syed Munib. A comparative clinical trial of artemether and quinine in Cerebral Malaria . RMJ. (2005), [cited December 05, 2023]; 30(2): 62-64.



Harvard Style

Sheraz Jamal Khan, Syed Munib (2005) A comparative clinical trial of artemether and quinine in Cerebral Malaria . RMJ, 30 (2), 62-64.



Turabian Style

Sheraz Jamal Khan, Syed Munib. 2005. A comparative clinical trial of artemether and quinine in Cerebral Malaria . Rawal Medical Journal, 30 (2), 62-64.



Chicago Style

Sheraz Jamal Khan, Syed Munib. "A comparative clinical trial of artemether and quinine in Cerebral Malaria ." Rawal Medical Journal 30 (2005), 62-64.



MLA (The Modern Language Association) Style

Sheraz Jamal Khan, Syed Munib. "A comparative clinical trial of artemether and quinine in Cerebral Malaria ." Rawal Medical Journal 30.2 (2005), 62-64. Print.



APA (American Psychological Association) Style

Sheraz Jamal Khan, Syed Munib (2005) A comparative clinical trial of artemether and quinine in Cerebral Malaria . Rawal Medical Journal, 30 (2), 62-64.