Bacteria causing urinary tract infection among children and their antimicrobial susceptibility patterns

Saeeda Nabat ul Hassan; Khushbu Farva; Ghulam Asghar Bhutta; Sadia Zia; Yasmeen Lashari; Mahreen Mahmood

Abstract
Objective: To determine frequency of common bacteria causing urinary tract infection (UTI) among toilet-trained children and their antimicrobial susceptibility pattern.
Methodology: This descriptive cross sectional study was carried out from October 2020 to March 2021 at Pathology unit of Sahara Medical College, Narowal, Pakistan. A total of 193 toilet-trained children with culture positive UTI were included in the study. Mid-stream urinary samples were collected and sent to institutional laboratory for urine analysis, culture and antimicrobial sensitivity patterns. Demographic details like gender, age, residential area, and clinical findings along with isolated microorganism and antimicrobial sensitivity pattern were recorded.
Results: Out of 193 children, 108(54%) were female and 85(46%) male. Mean age was 10.56±3.82 years (range 6-14). There were 114(57%) children above 10 years of age and 129(64.5%) belonged to rural areas. Most common bacteria isolated was E. coli in 155(80.3%) cases. Antimicrobials having highest sensitivity against the causative bacteria included Imipenem and Meropenem 189(97.9%), Piperacillin Tazobactam 187(96.9%), Amikacin 185(95.8%), Fosfomycin 184(95.3%), Gentamycin 178(92.2%) and Sulzone 171(88.6%).
Conclusion: Eschericia coli was the commonest bacteria causing UTI among toilet trained children. Antimicrobials with highest sensitivity included Imipenem, Meropenem, Piperacillin Tazobactam, Amikacin and Fosfomycin.

Key words: Urinary tract infection, Gram-negative bacteria, E. coli, toilet-trained children, antimicrobial sensitivity.

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