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2026, Vol: 51, Issue: 3
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Original Research 


Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies

Heny Syahrini, Andri Iskandar Mardia, Rina Yunita.


Abstract
Objective: To describe the epidemiological profile of multidrug-resistant organisms (MDROs) in patients with hematologic malignancies.
Methodology: This retrospective descriptive study was conducted at Haji Adam Malik General Hospital, Medan, Indonesia, from July 2022 to July 2023. Adult patients with hematologic malignancies and culture-proven bacterial infections were included. MDROs were defined as bacteria resistant to at least one agent in three or more antimicrobial categories. Data were analysed using SPSS version 29 and presented as mean values and percentages.
Results: Thirty-one patients yielded 43 bacterial isolates. The most common pathogens were Klebsiella pneumoniae (18.6%), Escherichia coli (16.3%), and Staphylococcus aureus (14.0%). High resistance was observed against cefotaxime (97.7%), chloramphenicol (90.7%), and amoxicillin (90.7%). Meropenem and amikacin showed the highest sensitivity. ESBL-producing isolates demonstrated 100% sensitivity to amikacin and 75% to meropenem.
Conclusion: Klebsiella pneumoniae was the predominant pathogen. Meropenem and amikacin remain effective options and may guide empirical antibiotic therapy.

Key words: Multidrug-resistant organisms, antibiotics, hematologic malignancy, bacterial culture.


 
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How to Cite this Article
Pubmed Style

Syahrini H, Mardia AI, Yunita R. Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. RMJ. 2026; 51(3): 666-670. doi:10.5455/rmj.20260209105412

Web Style

Syahrini H, Mardia AI, Yunita R. Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. https://www.rmj.org.pk/?mno=309893 [Access: August 19, 2026]. doi:10.5455/rmj.20260209105412

AMA (American Medical Association) Style

Syahrini H, Mardia AI, Yunita R. Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. RMJ. 2026; 51(3): 666-670. doi:10.5455/rmj.20260209105412


Vancouver/ICMJE Style

Syahrini H, Mardia AI, Yunita R. Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. RMJ. (2026), [cited August 19, 2026]; 51(3): 666-670. doi:10.5455/rmj.20260209105412


Harvard Style

Syahrini, H., Mardia, . A. I. & Yunita, . R. (2026) Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. RMJ, 51 (3), 666-670. doi:10.5455/rmj.20260209105412


Turabian Style

Syahrini, Heny, Andri Iskandar Mardia, and Rina Yunita. 2026. Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. Rawal Medical Journal, 51 (3), 666-670. doi:10.5455/rmj.20260209105412


Chicago Style

Syahrini, Heny, Andri Iskandar Mardia, and Rina Yunita. "Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies." Rawal Medical Journal 51 (2026), 666-670. doi:10.5455/rmj.20260209105412


MLA (The Modern Language Association) Style

Syahrini, Heny, Andri Iskandar Mardia, and Rina Yunita. "Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies." Rawal Medical Journal 51.3 (2026), 666-670. Print. doi:10.5455/rmj.20260209105412


APA (American Psychological Association) Style

Syahrini, H., Mardia, . A. I. & Yunita, . R. (2026) Epidemiological profile of multidrug-resistant organisms in patients with hematologic malignancies. Rawal Medical Journal, 51 (3), 666-670. doi:10.5455/rmj.20260209105412


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