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2026, Vol: 51, Issue: 1
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Original Research 


The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus)

Bagus Hibridiawan, Ashon Sa’adi, Widjiati Widjiati.


Abstract
Objective: To evaluate the effect of Kebar leaf extract on serum levels and ovarian expression of kisspeptin in a PCOS rat model.
Methodology: The study employed a randomized post-test-only control group design with rats as subjects. Rats were divided into three groups: a negative control, a positive control, and a treatment group, each receiving different doses of Kebar leaf extract (1.42 mg/g BW/day). Kisspeptin levels were measured from serum and ovarian tissues after treatment.
Results: Kebar leaf extract significantly increased average kisspeptin levels in rats compared to positive controls (p<0.001). This dosage also led to a significant decrease in the IRS score of kisspeptin expression (p=0.005), when compared to controls.
Conclusion: Kebar leaf extract at a dose of 1.42 mg/gBW/day in PCOS rats significantly increased kisspeptin levels and decreased the IRS score of kisspeptin expression.

Key words: Kebar leaf extract, kisspeptin, polycystic ovary syndrome.


 
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How to Cite this Article
Pubmed Style

Hibridiawan B, Sa'adi A, Widjiati W. The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). RMJ. 2026; 51(1): 238-241. doi:10.5455/rmj.20250702050647

Web Style

Hibridiawan B, Sa'adi A, Widjiati W. The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). https://www.rmj.org.pk/?mno=268279 [Access: February 21, 2026]. doi:10.5455/rmj.20250702050647

AMA (American Medical Association) Style

Hibridiawan B, Sa'adi A, Widjiati W. The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). RMJ. 2026; 51(1): 238-241. doi:10.5455/rmj.20250702050647


Vancouver/ICMJE Style

Hibridiawan B, Sa'adi A, Widjiati W. The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). RMJ. (2026), [cited February 21, 2026]; 51(1): 238-241. doi:10.5455/rmj.20250702050647


Harvard Style

Hibridiawan, B., Sa'adi, . A. & Widjiati, . W. (2026) The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). RMJ, 51 (1), 238-241. doi:10.5455/rmj.20250702050647


Turabian Style

Hibridiawan, Bagus, Ashon Sa'adi, and Widjiati Widjiati. 2026. The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). Rawal Medical Journal, 51 (1), 238-241. doi:10.5455/rmj.20250702050647


Chicago Style

Hibridiawan, Bagus, Ashon Sa'adi, and Widjiati Widjiati. "The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus)." Rawal Medical Journal 51 (2026), 238-241. doi:10.5455/rmj.20250702050647


MLA (The Modern Language Association) Style

Hibridiawan, Bagus, Ashon Sa'adi, and Widjiati Widjiati. "The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus)." Rawal Medical Journal 51.1 (2026), 238-241. Print. doi:10.5455/rmj.20250702050647


APA (American Psychological Association) Style

Hibridiawan, B., Sa'adi, . A. & Widjiati, . W. (2026) The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus). Rawal Medical Journal, 51 (1), 238-241. doi:10.5455/rmj.20250702050647


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