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2026, Vol: 51, Issue: 1
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Original Research 


Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study

Mi Ra Kim, Jieun Jeong.


Abstract
Objective: To characterize and compare the clinical, laboratory, and imaging profiles of light-chain (AL) and transthyretin (ATTR) cardiac amyloidosis in a single-center setting.
Methodology: We retrospectively analyzed 54 patients who underwent 99mTc-DPD SPECT-CT at our center between 2021-2024. Data collected included demographics, medical history, cardiac biomarkers, echocardiography results, and tissue biopsies. Myocardial uptake intensity was graded using the Perugini system (0-3).
Results: Nine patients were diagnosed with ATTR cardiac amyloidosis (ATTR-CM) and four with AL amyloidosis. ATTR-CM patients (62-84 years) and AL-CM patients (55-75 years) both presented with dyspnea and peripheral edema, but autonomic symptoms and extracardiac manifestations (carpal tunnel syndrome, lumbar stenosis) were more prevalent in ATTR-CM. All ATTR-CM patients demonstrated left ventricular hypertrophy, with eight showing concentric hypertrophy. AL amyloidosis patients exhibited no myocardial uptake on bone scintigraphy (grade 0).
Conclusion: The male predominance and concentric hypertrophy in ATTR-CM align with existing literature, while negative scintigraphy in AL cases reinforces its diagnostic utility.

Key words: Cardiac amyloidosis, transthyretin amyloidosis (ATTR), light-chain amyloidosis (AL), bone scintigraphy, echocardiography.


 
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Pubmed Style

Kim MR, Jeong J. Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. RMJ. 2026; 51(1): 51-56. doi:10.5455/rmj.20250322094602

Web Style

Kim MR, Jeong J. Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. https://www.rmj.org.pk/?mno=248742 [Access: February 25, 2026]. doi:10.5455/rmj.20250322094602

AMA (American Medical Association) Style

Kim MR, Jeong J. Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. RMJ. 2026; 51(1): 51-56. doi:10.5455/rmj.20250322094602


Vancouver/ICMJE Style

Kim MR, Jeong J. Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. RMJ. (2026), [cited February 25, 2026]; 51(1): 51-56. doi:10.5455/rmj.20250322094602


Harvard Style

Kim, M. R. & Jeong, . J. (2026) Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. RMJ, 51 (1), 51-56. doi:10.5455/rmj.20250322094602


Turabian Style

Kim, Mi Ra, and Jieun Jeong. 2026. Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. Rawal Medical Journal, 51 (1), 51-56. doi:10.5455/rmj.20250322094602


Chicago Style

Kim, Mi Ra, and Jieun Jeong. "Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study." Rawal Medical Journal 51 (2026), 51-56. doi:10.5455/rmj.20250322094602


MLA (The Modern Language Association) Style

Kim, Mi Ra, and Jieun Jeong. "Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study." Rawal Medical Journal 51.1 (2026), 51-56. Print. doi:10.5455/rmj.20250322094602


APA (American Psychological Association) Style

Kim, M. R. & Jeong, . J. (2026) Clinical characteristics and diagnostic profile of cardiac amyloidosis: A single-center retrospective study. Rawal Medical Journal, 51 (1), 51-56. doi:10.5455/rmj.20250322094602


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