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2025, Vol: 50, Issue: 1
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Original Research 
RMJ. 2025; 50(1): 125-127


Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder

Aafia Afridi, Muhammad Ayub Khan, Sarfaraz Khan, Haseeb Khaliq, Tasneem Azhar, Ehsan Khan.


Abstract
Objective: To investigate Polycystic ovary syndrome (PCOS) associated pathologies in term of decreased BDNF levels.
Methodology: Serum BDNF levels were quantified using Enzyme Linked Immunosorbent Assay (ELISA) from collected serum and follicular fluid samples from 100 PCOS patients and 60 healthy women as control.
Result: BDNF both in the serum (08 ng/ml) and in the follicular fluid (10ng/ml) of PCOS patients was lower in comparison to the control group (serum 25ng/ml, Follicular 17ng/ml) with statistical significance (p<0.001). Hypo-BDNF state was significantly negative in follicular fluid as compared to serum.
Conclusion: Chronic reduced BDNF levels in women with PCOS suggest that it can be used as a biomarker for disease severity and treatment efficacy. Low levels of BDNF may be in a causal relation to neuroendocrine and metabolic disturbances in PCOS.

Key words: BDNF, Polycystic Ovary Syndrome, metabolic disorder, multi-system disorder.


 
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How to Cite this Article
Pubmed Style

Afridi A, Khan MA, Khan S, Khaliq H, Azhar T, Khan E. Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. RMJ. 2025; 50(1): 125-127.

Web Style

Afridi A, Khan MA, Khan S, Khaliq H, Azhar T, Khan E. Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. https://www.rmj.org.pk/?mno=235245 [Access: March 12, 2025].

AMA (American Medical Association) Style

Afridi A, Khan MA, Khan S, Khaliq H, Azhar T, Khan E. Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. RMJ. 2025; 50(1): 125-127.


Vancouver/ICMJE Style

Afridi A, Khan MA, Khan S, Khaliq H, Azhar T, Khan E. Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. RMJ. (2025), [cited March 12, 2025]; 50(1): 125-127.


Harvard Style

Afridi, A., Khan, . M. A., Khan, . S., Khaliq, . H., Azhar, . T. & Khan, . E. (2025) Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. RMJ, 50 (1), 125-127.


Turabian Style

Afridi, Aafia, Muhammad Ayub Khan, Sarfaraz Khan, Haseeb Khaliq, Tasneem Azhar, and Ehsan Khan. 2025. Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. Rawal Medical Journal, 50 (1), 125-127.


Chicago Style

Afridi, Aafia, Muhammad Ayub Khan, Sarfaraz Khan, Haseeb Khaliq, Tasneem Azhar, and Ehsan Khan. "Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder." Rawal Medical Journal 50 (2025), 125-127.


MLA (The Modern Language Association) Style

Afridi, Aafia, Muhammad Ayub Khan, Sarfaraz Khan, Haseeb Khaliq, Tasneem Azhar, and Ehsan Khan. "Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder." Rawal Medical Journal 50.1 (2025), 125-127. Print.


APA (American Psychological Association) Style

Afridi, A., Khan, . M. A., Khan, . S., Khaliq, . H., Azhar, . T. & Khan, . E. (2025) Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder. Rawal Medical Journal, 50 (1), 125-127.


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