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2025, Vol: 50, Issue: 4
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Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study

Kumayl Abbas Meghji, Muhammad Uzair Memon, Adeel Rehman Siyal, Haji Abdullah Memon, Pranjal Wadhwani, Azka Khan.


Abstract
Objective: To examine the association between transfusion frequency, serum ferritin levels, and splenomegaly in β-thalassemia major (β-TM) patients.
Methodology: A cross-sectional study of 194 β-TM patients (0–18 years) was conducted at thalassemia center in Hyderabad, Pakistan. Data on demographics, transfusion frequency, serum ferritin, and chelation adherence were collected. Splenomegaly was assessed clinically and via ultrasonography. Pearson’s correlation and chi-square tests were applied, with p ≤ 0.05 considered significant.
Results: Splenomegaly was present in 61.34% of patients. Significant correlations were found between spleen size and transfusion frequency (r = 0.62, p<0.01), hemoglobin (r = -0.74, p<0.01), and bilirubin levels (r = 0.96, p<0.01). High transfusion rates (≥12/year), elevated ferritin (≥1500 ng/mL), and poor chelation adherence were strongly associated with splenomegaly (p<0.001).
Conclusion: Frequent transfusions and poor chelation adherence contribute to iron overload and splenomegaly in β-TM. Optimizing transfusion schedules and enhancing chelation compliance can improve outcomes.

Key words: Thalassemia, splenomegaly, ferritin, iron overload.


 
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How to Cite this Article
Pubmed Style

Meghji KA, Memon MU, Siyal AR, Memon HA, Wadhwani P, Khan A. Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. RMJ. 2025; 50(3): 615-619. doi:10.5455/rmj.20241224043952

Web Style

Meghji KA, Memon MU, Siyal AR, Memon HA, Wadhwani P, Khan A. Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. https://www.rmj.org.pk/?mno=234542 [Access: October 30, 2025]. doi:10.5455/rmj.20241224043952

AMA (American Medical Association) Style

Meghji KA, Memon MU, Siyal AR, Memon HA, Wadhwani P, Khan A. Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. RMJ. 2025; 50(3): 615-619. doi:10.5455/rmj.20241224043952


Vancouver/ICMJE Style

Meghji KA, Memon MU, Siyal AR, Memon HA, Wadhwani P, Khan A. Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. RMJ. (2025), [cited October 30, 2025]; 50(3): 615-619. doi:10.5455/rmj.20241224043952


Harvard Style

Meghji, K. A., Memon, . M. U., Siyal, . A. R., Memon, . H. A., Wadhwani, . P. & Khan, . A. (2025) Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. RMJ, 50 (3), 615-619. doi:10.5455/rmj.20241224043952


Turabian Style

Meghji, Kumayl Abbas, Muhammad Uzair Memon, Adeel Rehman Siyal, Haji Abdullah Memon, Pranjal Wadhwani, and Azka Khan. 2025. Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. Rawal Medical Journal, 50 (3), 615-619. doi:10.5455/rmj.20241224043952


Chicago Style

Meghji, Kumayl Abbas, Muhammad Uzair Memon, Adeel Rehman Siyal, Haji Abdullah Memon, Pranjal Wadhwani, and Azka Khan. "Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study." Rawal Medical Journal 50 (2025), 615-619. doi:10.5455/rmj.20241224043952


MLA (The Modern Language Association) Style

Meghji, Kumayl Abbas, Muhammad Uzair Memon, Adeel Rehman Siyal, Haji Abdullah Memon, Pranjal Wadhwani, and Azka Khan. "Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study." Rawal Medical Journal 50.3 (2025), 615-619. Print. doi:10.5455/rmj.20241224043952


APA (American Psychological Association) Style

Meghji, K. A., Memon, . M. U., Siyal, . A. R., Memon, . H. A., Wadhwani, . P. & Khan, . A. (2025) Impact of transfusion frequency and iron overload on splenomegaly in β-Thalassemia Major: A cross-sectional Study. Rawal Medical Journal, 50 (3), 615-619. doi:10.5455/rmj.20241224043952


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