Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy

Tooba Noor; Adeena Jamil; Hina Badar Afnan; Zareen Kiran; Muhammad Tassaduq Khan; Farina Hanif

2025, Vol: 50, Issue: 4

50 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Author_Certificate
Bank Reciept

« Previous Article

Original Research

RMJ. 2025; 50(1): 87-91

Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy

Tooba Noor, Adeena Jamil, Hina Badar Afnan, Zareen Kiran, Muhammad Tassaduq Khan, Farina Hanif.

Abstract
Objective: To investigate the relationship of copeptin, a surrogate marker of vasopressin with varying fluid intake among individuals with progressive stages of diabetic nephropathy.
Methodology: This retrospective analytical cross-sectional study was conducted on prediabetes, DM without nephropathy and DM with nephropathy and compared with controls. Biochemical tests and 24hr fluid intake history was taken. Sandwich based Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure serum copeptin levels.
Results: We found that 47.5% participants were consuming <6 glass of water per day. Black tea (30%), green tea (17%), coffee (13%) was mostly sought by these patients. Significant difference of decreased fluid intake was found with advancing age (p≤0.001), osmolarity (p=0.005), glycosylated hemoglobin (p=0.004), BUN (p≤0.001) and urinary albumin creatinine ratio (p=0.022). A trend of non-significant but progressively lower serum copeptin levels was observed with higher water consumption.
Conclusion: Limited fluid intake among subjects with nephropathy secondary to DM and its relationship with higher copeptin levels is the key finding of this study. This insinuate the role of AVP as a primary regulator of fluid homeostasis and suggest that limited fluid intake could be a low-cost metabolic intervention of regulating dangerously high AVP levels in DM.

Key words: Arginine vasopressin, copeptin, fluid, nephropathy, osmolarity, diabetes mellitus.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Tooba Noor Articles by Adeena Jamil Articles by Hina Badar Afnan Articles by Zareen Kiran Articles by Muhammad Tassaduq Khan Articles by Farina Hanif
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Noor T, Jamil A, Afnan HB, Kiran Z, Khan MT, Hanif F. Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy. RMJ. 2025; 50(1): 87-91.

Web Style

Noor T, Jamil A, Afnan HB, Kiran Z, Khan MT, Hanif F. Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy. https://www.rmj.org.pk/?mno=209896 [Access: October 30, 2025].

AMA (American Medical Association) Style

Noor T, Jamil A, Afnan HB, Kiran Z, Khan MT, Hanif F. Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy. RMJ. 2025; 50(1): 87-91.

Vancouver/ICMJE Style

Harvard Style

Noor, T., Jamil, . A., Afnan, . H. B., Kiran, . Z., Khan, . M. T. & Hanif, . F. (2025) Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy. RMJ, 50 (1), 87-91.

Turabian Style

Noor, Tooba, Adeena Jamil, Hina Badar Afnan, Zareen Kiran, Muhammad Tassaduq Khan, and Farina Hanif. 2025. Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy. Rawal Medical Journal, 50 (1), 87-91.

Chicago Style

Noor, Tooba, Adeena Jamil, Hina Badar Afnan, Zareen Kiran, Muhammad Tassaduq Khan, and Farina Hanif. "Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy." Rawal Medical Journal 50 (2025), 87-91.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Author Login Reviewer Login Editorial Policies Conflict of Interest Policy Plagiarism Policy Advertising Policy

About Rawal Medical Journal

Contact Information

How to cite this article


About Rawal Medical Journal Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information