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2024, Vol: 49, Issue: 4
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Original Research 
RMJ. 2024; 49(4): 734-737


C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome

Rabia Siddiqui, Nighat Rukhsana, Muhammad Sajid Abbas Jafri, Shazia Shakoor, Samreen Iqbal, Muhammad Younas.


Abstract
Objective: To investigate the association of serum CRP levels in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome.
Methodology: This comparative cross-sectional study included 120 subjects divided into 2 groups (60 obese >30kg/m2 and 60 non-obese <30kg/m2) type 2 diabetes mellitus patients with Metabolic Syndrome. The participants were taken from Medical OPD National Medical Center, Karachi from December 22 to May 23. The 2005 revised NCEP-ATP III criteria were used to determine Metabolic Syndrome. Fasting Blood Glucose (FBG), Triglycerides (TG), Total cholesterol (TC), Low density Lipoprotein (LDL-C), High density Lipoprotein (HDL-C) and C-Reactive Protein (CRP) were measured.
Results: We found that 75% of type 2 diabetes mellitus patients had metabolic syndrome. There were significant mean differences for waist circumference (WC), systolic blood pressure, FBG, and TG between metabolic syndrome and non-metabolic syndrome samples (p<0.05). The Multivariate linear regression analysis showed increase in WC giving 0.13-time positive impact on CRP (p<0.01). The difference in median CRP of obese and non-obese samples of metabolic samples was also statistically significant (p=0.01).
Conclusion: CRP levels were higher in obese than non-obese type 2 diabetic patients with metabolic syndrome.

Key words: Obesity, CRP, insulin resistance, type 2 diabetes mellitus and Metabolic Syndrome.


 
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How to Cite this Article
Pubmed Style

Siddiqui R, Rukhsana N, Jafri MSA, Shakoor S, Iqbal S, Younas M. C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. RMJ. 2024; 49(4): 734-737.

Web Style

Siddiqui R, Rukhsana N, Jafri MSA, Shakoor S, Iqbal S, Younas M. C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. https://www.rmj.org.pk/?mno=204645 [Access: November 16, 2024].

AMA (American Medical Association) Style

Siddiqui R, Rukhsana N, Jafri MSA, Shakoor S, Iqbal S, Younas M. C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. RMJ. 2024; 49(4): 734-737.


Vancouver/ICMJE Style

Siddiqui R, Rukhsana N, Jafri MSA, Shakoor S, Iqbal S, Younas M. C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. RMJ. (2024), [cited November 16, 2024]; 49(4): 734-737.


Harvard Style

Siddiqui, R., Rukhsana, . N., Jafri, . M. S. A., Shakoor, . S., Iqbal, . S. & Younas, . M. (2024) C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. RMJ, 49 (4), 734-737.


Turabian Style

Siddiqui, Rabia, Nighat Rukhsana, Muhammad Sajid Abbas Jafri, Shazia Shakoor, Samreen Iqbal, and Muhammad Younas. 2024. C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. Rawal Medical Journal, 49 (4), 734-737.


Chicago Style

Siddiqui, Rabia, Nighat Rukhsana, Muhammad Sajid Abbas Jafri, Shazia Shakoor, Samreen Iqbal, and Muhammad Younas. "C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome." Rawal Medical Journal 49 (2024), 734-737.


MLA (The Modern Language Association) Style

Siddiqui, Rabia, Nighat Rukhsana, Muhammad Sajid Abbas Jafri, Shazia Shakoor, Samreen Iqbal, and Muhammad Younas. "C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome." Rawal Medical Journal 49.4 (2024), 734-737. Print.


APA (American Psychological Association) Style

Siddiqui, R., Rukhsana, . N., Jafri, . M. S. A., Shakoor, . S., Iqbal, . S. & Younas, . M. (2024) C-reactive protein as an inflammatory marker in obese and non-obese type 2 diabetes mellitus patients with metabolic syndrome. Rawal Medical Journal, 49 (4), 734-737.


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