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Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study

Amena Rahim, Naila Zakria, Muhammad Afzal, Bushra Ghulam, Zahira Bashir, Syeda Sameen Zehra Rizvi.


Abstract
Objective: To determine the genetic associations of COMT gene polymorphism (rs4680) with stress induced Temporomandibular Disorders (TMD) in medical students.
Methodology: This case control study was conducted at Islamic International Medical College in collaboration with Dental Center of Railway Hospital and Dental College of Heavy Industries Taxila Educational City, from November 2022 to October 2023. It included 126 cases with stress induced TMD and 126 matched controls without TMD and stress. All were medical students, both undergraduate and postgraduate. Peripheral blood was taken to extract DNA and genotyped for COMT polymorphism (rs4680) by Tetra-ARMS PCR. The association was determined by calculating Odds ratio and 95% confidence interval.
Result: COMT gene polymorphism (rs4680) G > A substitution was significantly associated with stress induced TMD (p<0.0001).
Conclusion: COMT (rs4680) may be considered a significant risk factor in the development of stress induced TMD in the medical students.

Key words: COMT (rs4680), temporomandibular disorders, psychological stress, genetic polymorphism.


 
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How to Cite this Article
Pubmed Style

Rahim A, Zakria N, Afzal M, Ghulam B, Bashir Z, Rizvi SSZ. Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. RMJ. 2025; 50(1): 109-112. doi:10.5455/rmj.20240113080818

Web Style

Rahim A, Zakria N, Afzal M, Ghulam B, Bashir Z, Rizvi SSZ. Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. https://www.rmj.org.pk/?mno=185161 [Access: March 12, 2025]. doi:10.5455/rmj.20240113080818

AMA (American Medical Association) Style

Rahim A, Zakria N, Afzal M, Ghulam B, Bashir Z, Rizvi SSZ. Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. RMJ. 2025; 50(1): 109-112. doi:10.5455/rmj.20240113080818


Vancouver/ICMJE Style

Rahim A, Zakria N, Afzal M, Ghulam B, Bashir Z, Rizvi SSZ. Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. RMJ. (2025), [cited March 12, 2025]; 50(1): 109-112. doi:10.5455/rmj.20240113080818


Harvard Style

Rahim, A., Zakria, . N., Afzal, . M., Ghulam, . B., Bashir, . Z. & Rizvi, . S. S. Z. (2025) Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. RMJ, 50 (1), 109-112. doi:10.5455/rmj.20240113080818


Turabian Style

Rahim, Amena, Naila Zakria, Muhammad Afzal, Bushra Ghulam, Zahira Bashir, and Syeda Sameen Zehra Rizvi. 2025. Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. Rawal Medical Journal, 50 (1), 109-112. doi:10.5455/rmj.20240113080818


Chicago Style

Rahim, Amena, Naila Zakria, Muhammad Afzal, Bushra Ghulam, Zahira Bashir, and Syeda Sameen Zehra Rizvi. "Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study." Rawal Medical Journal 50 (2025), 109-112. doi:10.5455/rmj.20240113080818


MLA (The Modern Language Association) Style

Rahim, Amena, Naila Zakria, Muhammad Afzal, Bushra Ghulam, Zahira Bashir, and Syeda Sameen Zehra Rizvi. "Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study." Rawal Medical Journal 50.1 (2025), 109-112. Print. doi:10.5455/rmj.20240113080818


APA (American Psychological Association) Style

Rahim, A., Zakria, . N., Afzal, . M., Ghulam, . B., Bashir, . Z. & Rizvi, . S. S. Z. (2025) Considering G>A polymorphism of COMT gene (rs4680), The genetic cause of stress induced TMD in medical students; A case control study. Rawal Medical Journal, 50 (1), 109-112. doi:10.5455/rmj.20240113080818


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