Whole Stevia leaf powder or Rebaudioside A; Effects of  supplementation on obesity induced oxidative stress

Amna Faruqi; Sadia Mubarak; Sikander Subuctageen; Tooba Zafar; Saima Latif Qureishi; Asma Irfan

2024, Vol: 49, Issue: 4

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RMJ. 2024; 49(4): 988-991

Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress

Amna Faruqi, Sadia Mubarak, Sikander Subuctageen, Tooba Zafar, Saima Latif Qureishi, Asma Irfan.

Abstract
Objective: To determine and compare the effect of diet supplementation with dry, powdered Stevia leaf and its highly purified Rebaudioside A glycoside, on obesity induced oxidative stress in a murine model.
Methodology: This experimental study included 120 Sprague Dawley male rats divided in four groups with 30 animals in each group. Normal control (Group 1, n=30), was fed an ordinary diet. Ninety rats were made obese by administration of a high fat diet (HFD) for eight weeks and after confirmation of obesity, using Lee Index, were randomly allocated to group 2 (Obese control), group 3 (obese+Stevia) and group 4 (Obese+Rebaudioside A). HFD was continued for a further six weeks along with supplementation with Stevia leaf powder (group 3) and Rebaudioside A (group 4). Oxidative stress was determined by testing testicular tissue supernatant for Malondialdehyde (MDA) and Catalase (CAT) activity using animal kits.
Results: Obesity caused a significant increase in tissue levels of MDA (p<0.001), and activity of Catalase (p<0.001). The administration of Stevia in group 3 showed a significant reduction in tissue MDA levels (p<0.001), while tissue catalase activity indicated a significant increase (p=0.006). Supplementation with Rebaudioside A resulted in a non-significant reduction in tissue MDA level (p=0.055). However, tissue catalase levels were significantly increased (p=0.019)
Conclusion: Both preparations possess anti-oxidative activity, however whole stevia leaf powder was found to be more effective than Rebaudioside A in improving oxidative status.

Key words: Oxidative stress, antioxidant, obesity, nutraceutical, stevia, Rebaudioside A.

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How to Cite this Article

Pubmed Style

Faruqi A, Mubarak S, Subuctageen S, Zafar T, Qureishi SL, Irfan A. Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. RMJ. 2024; 49(4): 988-991.

Web Style

Faruqi A, Mubarak S, Subuctageen S, Zafar T, Qureishi SL, Irfan A. Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. https://www.rmj.org.pk/?mno=176483 [Access: November 17, 2024].

AMA (American Medical Association) Style

Faruqi A, Mubarak S, Subuctageen S, Zafar T, Qureishi SL, Irfan A. Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. RMJ. 2024; 49(4): 988-991.

Vancouver/ICMJE Style

Faruqi A, Mubarak S, Subuctageen S, Zafar T, Qureishi SL, Irfan A. Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. RMJ. (2024), [cited November 17, 2024]; 49(4): 988-991.

Harvard Style

Faruqi, A., Mubarak, . S., Subuctageen, . S., Zafar, . T., Qureishi, . S. L. & Irfan, . A. (2024) Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. RMJ, 49 (4), 988-991.

Turabian Style

Faruqi, Amna, Sadia Mubarak, Sikander Subuctageen, Tooba Zafar, Saima Latif Qureishi, and Asma Irfan. 2024. Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress. Rawal Medical Journal, 49 (4), 988-991.

Chicago Style

Faruqi, Amna, Sadia Mubarak, Sikander Subuctageen, Tooba Zafar, Saima Latif Qureishi, and Asma Irfan. "Whole Stevia leaf powder or Rebaudioside A; Effects of supplementation on obesity induced oxidative stress." Rawal Medical Journal 49 (2024), 988-991.

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