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Original Research 
RMJ. 2022; 47(3): 622-626


Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy

Ayesha Shahid, Salman Maqbool, Sidra Shabbir.

Abstract
Objective: To compare Nalbuphine with Dexmedetomidine for postoperative analgesia in laparoscopic cholecystectomy.
Methodology: This study was done at Anesthesia Department, Rawal Institute of Health Sciences Islamabad from 15thApril 2019 to 30thSept 2019. Sixty patients (30 in each group) with age 20-60 years having ASA10physical status class I, II, undergoing elective laparoscopic cholecystectomy were included. Group-A, patients were given injection Nalbuphine 0.1mg/kg at induction of anesthesia and group B patients were given injection Dexmedetomidine 1µg/kg 15 min before induction. After premedication with injection Midazolam 2 mg I/V and inj. ondansetron 4mg I/Induction of anesthesia was done with injection Propofol 2mg/kg. Injection paracetamol 1 gm was given intravenously in all patients. Anesthesia was maintained by mixture of 50% nitrous oxide in oxygen and 2% sevoflurane. Injection cisatracuium 20µg/kg was used for maintenance of muscle relaxation.
Standard hemodynamic monitoring was done intraoperatively. At the end of surgery, residual neuromuscular blockade was reversed by injection neostigmine 30µg/kg along with atropine 15µg/kg intravenously. Patients were extubated and monitored in recovery room and were followed postoperatively for onset of pain (VAS used for assessment) and total analgesic requirement in 24-hours (in equivalent doses of morphine) post-operative nausea vomiting, sedation score and shivering. Statistical analysis was done by SPSS 21.
Results: There was no statistically significant difference in demographic profile, intraoperative hemodynamic parameters in two groups except for post extubation phase when a sudden rise was observed in HR and BP in Nalbuphine group. There was statistically significant difference in postoperative onset of pain (279/734 minutes with p value 0.000), VAS score (6.6/3.07 with p-value 0.000), 24 hour analgesic requirement in equivalent dose of morphine (17/10 mg with p value 0.000), sedation score (p value 0.000), postoperative shivering (63.3% versus 16.7% with p value 0.000) and postoperative vomiting (70% versus 20% with p value 0.000) in both groups A and B, respectively. However no difference was observed in incidence of hypotension (6.7% versus 3.3% with p value 0.554) .

Key words: Laproscopic cholecystectomy, nalbuphine, dexmedetomidine.


 
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How to Cite this Article
Pubmed Style

Shahid A, Maqbool S, Shabbir S. Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. RMJ. 2022; 47(3): 622-626.


Web Style

Shahid A, Maqbool S, Shabbir S. Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. https://www.rmj.org.pk/?mno=124717 [Access: September 02, 2022].


AMA (American Medical Association) Style

Shahid A, Maqbool S, Shabbir S. Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. RMJ. 2022; 47(3): 622-626.



Vancouver/ICMJE Style

Shahid A, Maqbool S, Shabbir S. Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. RMJ. (2022), [cited September 02, 2022]; 47(3): 622-626.



Harvard Style

Shahid, A., Maqbool, . S. & Shabbir, . S. (2022) Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. RMJ, 47 (3), 622-626.



Turabian Style

Shahid, Ayesha, Salman Maqbool, and Sidra Shabbir. 2022. Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. Rawal Medical Journal, 47 (3), 622-626.



Chicago Style

Shahid, Ayesha, Salman Maqbool, and Sidra Shabbir. "Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy." Rawal Medical Journal 47 (2022), 622-626.



MLA (The Modern Language Association) Style

Shahid, Ayesha, Salman Maqbool, and Sidra Shabbir. "Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy." Rawal Medical Journal 47.3 (2022), 622-626. Print.



APA (American Psychological Association) Style

Shahid, A., Maqbool, . S. & Shabbir, . S. (2022) Comparison of nalbuphine with dexmedetomidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. Rawal Medical Journal, 47 (3), 622-626.








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