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Original Research 
RMJ. 2021; 46(2): 274-277


Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard

Jamila Farid, Muhammad Idris, Nasreen Gul.

Abstract
Objective: To determine the sensitivity, specificity, positive predictive value and negative predictive value of Immuno-chromatographic test (ICT) in patients with visceral Leishmaniasis simultaneously diagnosed by examination of bone marrow aspirate, a gold standard test.
Methodology: This descriptive cross sectional study was conducted at a tertiary care hospital from February 2016 to February 2020 on 55 consecutive patients from endemic areas with clinical suspicion of visceral Leishmaniasis, coming for bone marrow examination. A nonrandom convenience sampling technique after informed written consent. Bone marrow was aspirated from each patient under local anesthesia, followed by 3 ml venous blood sample. The ICT was done by trained personal that was kept blind of the prior diagnosis of visceral Leishmaniasis. The data obtained were analyzed by SPSS-24.
Results: Age group <5 years was commonest among affected with male predominance, followed by 5-10 years & >10 years. The ICT was positive in 49/55 (87.27%) and negative in 6/55 (12.73%). Bone marrow examination revealed LD bodies in 50/55 (90.91%) and no LD bodies in 05(9.09%) patients.
Conclusion: ICT had high sensitivity and positive predictive value, but comparatively low specificity and negative predictive value for visceral Leishmaniasis. It should not be used as a single confirmatory test for visceral leishmaniasis.

Key words: Leishmaniasis, visceral, rapid diagnostic test.


 
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How to Cite this Article
Pubmed Style

Farid J, Idris M, Gul N. Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. RMJ. 2021; 46(2): 274-277.


Web Style

Farid J, Idris M, Gul N. Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. http://www.rmj.org.pk/?mno=116742 [Access: June 12, 2021].


AMA (American Medical Association) Style

Farid J, Idris M, Gul N. Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. RMJ. 2021; 46(2): 274-277.



Vancouver/ICMJE Style

Farid J, Idris M, Gul N. Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. RMJ. (2021), [cited June 12, 2021]; 46(2): 274-277.



Harvard Style

Farid, J., Idris, . M. & Gul, . N. (2021) Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. RMJ, 46 (2), 274-277.



Turabian Style

Farid, Jamila, Muhammad Idris, and Nasreen Gul. 2021. Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. Rawal Medical Journal, 46 (2), 274-277.



Chicago Style

Farid, Jamila, Muhammad Idris, and Nasreen Gul. "Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard." Rawal Medical Journal 46 (2021), 274-277.



MLA (The Modern Language Association) Style

Farid, Jamila, Muhammad Idris, and Nasreen Gul. "Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard." Rawal Medical Journal 46.2 (2021), 274-277. Print.



APA (American Psychological Association) Style

Farid, J., Idris, . M. & Gul, . N. (2021) Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard. Rawal Medical Journal, 46 (2), 274-277.








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