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Original Research
Online Published: 13 Sep 2026
 
RMJ. 2026; 51(4): 1051-1055

doi: 10.5455/rmj.20260220090724


Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy

Ghazala Jawwad, Shazia Ali, Sana Nawab, Maryam Khizar Hayat, Shagufta Feroz.


Abstract
Objective: To evaluate the role of blood inflammatory indices-mean platelet volume (MPV), platelet distribution width (PDW), and neutrophil-to-lymphocyte ratio (NLR)-in predicting intrahepatic cholestasis of pregnancy (ICP).
Methodology: This prospective cohort study included 182 pregnant females. Alanine transaminase (ALT), total bile acids (TBA), and blood inflammatory indices (MPV, PDW, and NLR) were recorded twice: once in the second trimester and again in the third trimester. ICP was defined as pruritus with elevated TBA levels >10 μmol/L.
Results: MPV, PDW, and NLR were significantly higher in women who developed ICP compared to controls. On multivariate logistic regression analysis, MPV emerged as the strongest independent predictor of ICP.
Conclusion: Early trimester increase in MPV and PDW can predict the development of ICP. MPV remains the strongest independent predictor of ICP after adjustment for confounders.

Key words: Intrahepatic cholestasis of pregnancy, Mean platelet volume, neutrophil-to-lymphocyte ratio, Total bile acids.


 
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How to Cite this Article
Pubmed Style

Jawwad G, Ali S, Nawab S, Hayat MK, Feroz S. Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. RMJ. 2026; 51(4): 1051-1055.

doi:10.5455/rmj.20260220090724

Web Style

Jawwad G, Ali S, Nawab S, Hayat MK, Feroz S. Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. https://www.rmj.org.pk/?mno=311164 [Access: November 11, 2026].

doi:10.5455/rmj.20260220090724

AMA (American Medical Association) Style

Jawwad G, Ali S, Nawab S, Hayat MK, Feroz S. Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. RMJ. 2026; 51(4): 1051-1055.


doi:10.5455/rmj.20260220090724

Vancouver/ICMJE Style

Jawwad G, Ali S, Nawab S, Hayat MK, Feroz S. Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. RMJ. (2026), [cited November 11, 2026]; 51(4): 1051-1055.


doi:10.5455/rmj.20260220090724

Harvard Style

Jawwad, G., Ali, . S., Nawab, . S., Hayat, . M. K. & Feroz, . S. (2026) Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. RMJ, 51 (4), 1051-1055.


doi:10.5455/rmj.20260220090724

Turabian Style

Jawwad, Ghazala, Shazia Ali, Sana Nawab, Maryam Khizar Hayat, and Shagufta Feroz. 2026. Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. Rawal Medical Journal, 51 (4), 1051-1055.


doi:10.5455/rmj.20260220090724

Chicago Style

Jawwad, Ghazala, Shazia Ali, Sana Nawab, Maryam Khizar Hayat, and Shagufta Feroz. "Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy." Rawal Medical Journal 51 (2026), 1051-1055.


doi:10.5455/rmj.20260220090724

MLA (The Modern Language Association) Style

Jawwad, Ghazala, Shazia Ali, Sana Nawab, Maryam Khizar Hayat, and Shagufta Feroz. "Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy." Rawal Medical Journal 51.4 (2026), 1051-1055. Print.


doi:10.5455/rmj.20260220090724

APA (American Psychological Association) Style

Jawwad, G., Ali, . S., Nawab, . S., Hayat, . M. K. & Feroz, . S. (2026) Elucidating the role of blood inflammatory markers in predicting Intrahepatic Cholestasis of Pregnancy. Rawal Medical Journal, 51 (4), 1051-1055.


doi:10.5455/rmj.20260220090724

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