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Original Research
Online Published: 01 Sep 2026
 
RMJ. 2026; 51(4): 991-995


Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study

Sara Dilshad, Ghulam Mustafa, Muhammad Khaleel Iqbal, Imran Shahid, Munir Ahmad Bhinder, Shahida Mohsin.


Abstract
Objective: To compare mean platelet volume (MPV) and serum thrombopoietin (TPO) levels in patients with acute coronary syndrome (ACS) versus healthy controls, and to examine the association of TPO A5713G polymorphism with ACS.
Methodology: This cross-sectional comparative study included 80 participants: 40 ACS patients and 40 age- and sex-matched healthy controls. MPV was measured using complete blood count, and serum TPO levels were assessed by enzyme-linked immunosorbent assay (ELISA). Genotyping for the TPO A5713G polymorphism was conducted using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).
Results: MPV was significantly higher in ACS patients (p<0.001), as were serum TPO levels (p=0.016), compared to controls. The GG genotype was more prevalent in ACS cases (p=0.500), and the G allele was also more frequent (p=0.268), though these differences were not statistically significant.
Conclusion: ACS patients demonstrated elevated MPV and TPO levels, which may indicate increased platelet production or activity. However, no significant association was observed between the A5713G polymorphism and ACS in this population.

Key words: Acute coronary syndrome, thrombopoietin, mean platelet volume, A5713G polymorphism, platelets.


 
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How to Cite this Article
Pubmed Style

Dilshad S, Mustafa G, Iqbal MK, Shahid I, Bhinder MA, Mohsin S. Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. RMJ. 2026; 51(4): 991-995.

Web Style

Dilshad S, Mustafa G, Iqbal MK, Shahid I, Bhinder MA, Mohsin S. Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. https://www.rmj.org.pk/?mno=282152 [Access: November 11, 2026].

AMA (American Medical Association) Style

Dilshad S, Mustafa G, Iqbal MK, Shahid I, Bhinder MA, Mohsin S. Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. RMJ. 2026; 51(4): 991-995.


Vancouver/ICMJE Style

Dilshad S, Mustafa G, Iqbal MK, Shahid I, Bhinder MA, Mohsin S. Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. RMJ. (2026), [cited November 11, 2026]; 51(4): 991-995.


Harvard Style

Dilshad, S., Mustafa, . G., Iqbal, . M. K., Shahid, . I., Bhinder, . M. A. & Mohsin, . S. (2026) Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. RMJ, 51 (4), 991-995.


Turabian Style

Dilshad, Sara, Ghulam Mustafa, Muhammad Khaleel Iqbal, Imran Shahid, Munir Ahmad Bhinder, and Shahida Mohsin. 2026. Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. Rawal Medical Journal, 51 (4), 991-995.


Chicago Style

Dilshad, Sara, Ghulam Mustafa, Muhammad Khaleel Iqbal, Imran Shahid, Munir Ahmad Bhinder, and Shahida Mohsin. "Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study." Rawal Medical Journal 51 (2026), 991-995.


MLA (The Modern Language Association) Style

Dilshad, Sara, Ghulam Mustafa, Muhammad Khaleel Iqbal, Imran Shahid, Munir Ahmad Bhinder, and Shahida Mohsin. "Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study." Rawal Medical Journal 51.4 (2026), 991-995. Print.


APA (American Psychological Association) Style

Dilshad, S., Mustafa, . G., Iqbal, . M. K., Shahid, . I., Bhinder, . M. A. & Mohsin, . S. (2026) Comparison of Mean Platelet Volume, Thrombopoietin Levels, and A5713G Polymorphism in Pakistani patients with acute coronary syndrome and healthy controls: A cross-sectional study. Rawal Medical Journal, 51 (4), 991-995.



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