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Original Research
Online Published: 31 Aug 2026
 
RMJ. 2026; 51(4): 1065-1069


Impact of single-dose oral azithromycin during labor on maternal and neonatal infections

Madiha Ahmed, Nayla Salman, Shermeen Kousar, Anum Mujeeb, Rubina Jabeen, Ambreen Fatima.


Abstract
Objective: To assess the impact of single-dose oral azithromycin during labor on maternal and neonatal infections.
Methodology: This randomized controlled trial was conducted at the Obstetrics & Gynecology Department of Fauji Foundation Hospital, Rawalpindi, from 1st May to 01st September 2025. Four hundred pregnant patients presenting with more than 28 weeks of gestational age were studied; 200 were placed in one group labelled as the intervention group, and 200 in another group labelled as the placebo group. Patients in the intervention group were given azithromycin 2g orally when in active labor, while patients in the placebo group received only standard intrapartum management.
Results: Infection rates were significantly reduced in the intervention group, where the patients received azithromycin. 5% of the patients in the azithromycin group developed infection in the perineal region. On the other hand, 11% women in the placebo group had perineal infection (p<0.05). There was also a reduction of the rate of endometritis in the intervention group as compared to the placebo group (p=0.03). The women in the intervention group had fewer urinary tract infections. There was also a marked reduction in the rate of neonatal sepsis in the neonates born to mothers who received azithromycin (p<0.05).
Conclusion: A single oral dose of azithromycin can be used to reduce the incidence of infections in the mother as well as their newborn babies in the immediate perinatal period.

Key words: infection, neonate, oral Antibiotics, peripartum, sepsis.


 
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How to Cite this Article
Pubmed Style

Ahmed M, Salman N, Kousar S, Mujeeb A, Jabeen R, Fatima A. Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. RMJ. 2026; 51(4): 1065-1069.

Web Style

Ahmed M, Salman N, Kousar S, Mujeeb A, Jabeen R, Fatima A. Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. https://www.rmj.org.pk/?mno=281500 [Access: November 11, 2026].

AMA (American Medical Association) Style

Ahmed M, Salman N, Kousar S, Mujeeb A, Jabeen R, Fatima A. Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. RMJ. 2026; 51(4): 1065-1069.


Vancouver/ICMJE Style

Ahmed M, Salman N, Kousar S, Mujeeb A, Jabeen R, Fatima A. Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. RMJ. (2026), [cited November 11, 2026]; 51(4): 1065-1069.


Harvard Style

Ahmed, M., Salman, . N., Kousar, . S., Mujeeb, . A., Jabeen, . R. & Fatima, . A. (2026) Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. RMJ, 51 (4), 1065-1069.


Turabian Style

Ahmed, Madiha, Nayla Salman, Shermeen Kousar, Anum Mujeeb, Rubina Jabeen, and Ambreen Fatima. 2026. Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. Rawal Medical Journal, 51 (4), 1065-1069.


Chicago Style

Ahmed, Madiha, Nayla Salman, Shermeen Kousar, Anum Mujeeb, Rubina Jabeen, and Ambreen Fatima. "Impact of single-dose oral azithromycin during labor on maternal and neonatal infections." Rawal Medical Journal 51 (2026), 1065-1069.


MLA (The Modern Language Association) Style

Ahmed, Madiha, Nayla Salman, Shermeen Kousar, Anum Mujeeb, Rubina Jabeen, and Ambreen Fatima. "Impact of single-dose oral azithromycin during labor on maternal and neonatal infections." Rawal Medical Journal 51.4 (2026), 1065-1069. Print.


APA (American Psychological Association) Style

Ahmed, M., Salman, . N., Kousar, . S., Mujeeb, . A., Jabeen, . R. & Fatima, . A. (2026) Impact of single-dose oral azithromycin during labor on maternal and neonatal infections. Rawal Medical Journal, 51 (4), 1065-1069.



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