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Original Research 
RMJ. 2026; 51(3): 757-760


Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome

Anum Ajmal, Beenish Riaz, Huma Afridi, Angbeen Ahmad, Saman Ahmad, Itaat Ullah Khan Afridi.


Abstract
Objective: To compare the efficacy of metformin and pioglitazone in women with polycystic ovarian syndrome (PCOS).
Methodology: This Randomized controlled trial was conducted at the Department of Obs & Gynae, Imran Idrees Teaching Hospital, Sialkot Medical College, Sialkot, from 1st June 2024 to 30th November 2024. Seventy patients of PCOS were included in the study. They were randomly allocated to two groups by lottery method. Patients in Group A were started on pioglitazone therapy and Group B on metformin. All the patients were assessed for the efficacy both drugs. Data were analyzed in SPSS version 25, and p≤ 0.05 was considered significant.
Results: The mean age of females in group A was 28.48±4.82 years and in group B was 27.6±5.34 years. Group A achieved efficacy in 21(60%) cases while Group B achieved efficacy in 27(77.1%) (p=0.122).
Conclusion: Both metformin and pioglitazone were effective in the treatment of women with PCOS. Pioglitazone does offer a useful, alternate treatment in women with PCOS who are not able to tolerate metformin.

Key words: Polycystic ovarian syndrome, efficacy, metformin, pioglitazone.


 
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How to Cite this Article
Pubmed Style

Ajmal A, Riaz B, Afridi H, Ahmad A, Ahmad S, Afridi IUK. Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. RMJ. 2026; 51(3): 757-760.

Web Style

Ajmal A, Riaz B, Afridi H, Ahmad A, Ahmad S, Afridi IUK. Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. https://www.rmj.org.pk/?mno=245420 [Access: August 19, 2026].

AMA (American Medical Association) Style

Ajmal A, Riaz B, Afridi H, Ahmad A, Ahmad S, Afridi IUK. Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. RMJ. 2026; 51(3): 757-760.


Vancouver/ICMJE Style

Ajmal A, Riaz B, Afridi H, Ahmad A, Ahmad S, Afridi IUK. Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. RMJ. (2026), [cited August 19, 2026]; 51(3): 757-760.


Harvard Style

Ajmal, A., Riaz, . B., Afridi, . H., Ahmad, . A., Ahmad, . S. & Afridi, . I. U. K. (2026) Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. RMJ, 51 (3), 757-760.


Turabian Style

Ajmal, Anum, Beenish Riaz, Huma Afridi, Angbeen Ahmad, Saman Ahmad, and Itaat Ullah Khan Afridi. 2026. Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. Rawal Medical Journal, 51 (3), 757-760.


Chicago Style

Ajmal, Anum, Beenish Riaz, Huma Afridi, Angbeen Ahmad, Saman Ahmad, and Itaat Ullah Khan Afridi. "Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome." Rawal Medical Journal 51 (2026), 757-760.


MLA (The Modern Language Association) Style

Ajmal, Anum, Beenish Riaz, Huma Afridi, Angbeen Ahmad, Saman Ahmad, and Itaat Ullah Khan Afridi. "Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome." Rawal Medical Journal 51.3 (2026), 757-760. Print.


APA (American Psychological Association) Style

Ajmal, A., Riaz, . B., Afridi, . H., Ahmad, . A., Ahmad, . S. & Afridi, . I. U. K. (2026) Comparison of metformin and pioglitazone in women with polycystic ovarian syndrome. Rawal Medical Journal, 51 (3), 757-760.


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