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Original Research 


Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study

Sri Lestariningsih, Didik Gunawan Tamtomo, Sri Sulistyowati, Dono Indarto, Imam Subadi.


Abstract
Objective: To evaluate the PGF2 profile and its association with symptoms in several models of primary dysmenorrhea.
Methodogy: The rats were placed into four groups, each with ten rats: control, primary dysmenorrhea 1 (PD1), primary dysmenorrhea 2 (PD2), and primary dysmenorrhea 3 (PD3). The pain as main dysmenorrhea symptom was assessed by observing writhing latency and frequency. The enzyme linked immunosorbent assay method was used to evaluate PGF2 levels in serum. Using hematoxyline eosin staining, the uterus was examined histopathologically. Results: The PD3 model had writhing characteristics, PGF2 levels, and degree of inflammation that are comparable to the PD2 model.
Conclusions: Our proposed PD model has clinical and biomolecular and histopathological characteristics comparable to existing models. Thus, this new model can be an alternative for modeling primary dysmenorrhea.

Key words: Primary dysmenorrhea, inflammation, uterus, prostaglandins, experimental animal models.


 
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How to Cite this Article
Pubmed Style

Lestariningsih S, Tamtomo DG, Sulistyowati S, Indarto D, Subadi I. Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. RMJ. 2024; 49(1): 176-180. doi:10.5455/rmj.20230803092427

Web Style

Lestariningsih S, Tamtomo DG, Sulistyowati S, Indarto D, Subadi I. Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. https://www.rmj.org.pk/?mno=163677 [Access: February 15, 2024]. doi:10.5455/rmj.20230803092427

AMA (American Medical Association) Style

Lestariningsih S, Tamtomo DG, Sulistyowati S, Indarto D, Subadi I. Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. RMJ. 2024; 49(1): 176-180. doi:10.5455/rmj.20230803092427


Vancouver/ICMJE Style

Lestariningsih S, Tamtomo DG, Sulistyowati S, Indarto D, Subadi I. Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. RMJ. (2024), [cited February 15, 2024]; 49(1): 176-180. doi:10.5455/rmj.20230803092427


Harvard Style

Lestariningsih, S., Tamtomo, . D. G., Sulistyowati, . S., Indarto, . D. & Subadi, . I. (2024) Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. RMJ, 49 (1), 176-180. doi:10.5455/rmj.20230803092427


Turabian Style

Lestariningsih, Sri, Didik Gunawan Tamtomo, Sri Sulistyowati, Dono Indarto, and Imam Subadi. 2024. Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. Rawal Medical Journal, 49 (1), 176-180. doi:10.5455/rmj.20230803092427


Chicago Style

Lestariningsih, Sri, Didik Gunawan Tamtomo, Sri Sulistyowati, Dono Indarto, and Imam Subadi. "Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study." Rawal Medical Journal 49 (2024), 176-180. doi:10.5455/rmj.20230803092427


MLA (The Modern Language Association) Style

Lestariningsih, Sri, Didik Gunawan Tamtomo, Sri Sulistyowati, Dono Indarto, and Imam Subadi. "Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study." Rawal Medical Journal 49.1 (2024), 176-180. Print. doi:10.5455/rmj.20230803092427


APA (American Psychological Association) Style

Lestariningsih, S., Tamtomo, . D. G., Sulistyowati, . S., Indarto, . D. & Subadi, . I. (2024) Three models of primary dysmenorrhea via estradiol benzoate and oxytocin induction: an experimental study. Rawal Medical Journal, 49 (1), 176-180. doi:10.5455/rmj.20230803092427


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