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Original Research 
RMJ. 2024; 49(2): 427-430


Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats

Shazia Ali, Tooba Jamal, Aysha Mushtaq, Shagufta Feroz.


Abstract
Objective: To compare and correlate serum cortisol and lipid profile among different groups of Male Sprague Dawley rats exposed to the stressors of immobilization and fasting while consuming standard lab diet, probiotics and synbiotics.
Methodology: This randomized control trial was carried out at Islamic International Medical College from September 2021 to September 2022, on 50 male Sprague Dawley rats. These were divided into Control-A (10 rats) and Experimental groups B1, B2, B3, and B4 (10 rats each), which were subjected to stressors of immobilizations (2 hours/5 days/10 weeks) and fasting 10 hours/5 days/10 weeks. Group B1 was given an extra 2 hours of fasting. Standard lab food for B1 and B2 while B3 received a conventional lab diet supplemented with probiotics. B4 received a standard lab diet supplemented with synbiotics. Serum cortisol and lipid profile was measured at 0, 4, and 10 weeks.
Results: Group B4 shows significant reduction (p≤0.001) in cortisol and lipid profile except HDL on comparison with other groups after 10 weeks. There was positive correlation between serum cortisol and cholesterol (0.840), triglyceride (0.741) and LDL (0.879) and negative correlation between serum cortisol and HDL -0.799.
Conclusion: Synbiotics ameliorate raised levels of cortisol and lipid profile due to stress exposure.

Key words: Stress, hypothalamic-pituitary axis, cortisol, lipid profile, synbiotics.


 
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How to Cite this Article
Pubmed Style

Ali S, Jamal T, Mushtaq A, Feroz S. Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. RMJ. 2024; 49(2): 427-430.

Web Style

Ali S, Jamal T, Mushtaq A, Feroz S. Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. https://www.rmj.org.pk/?mno=156467 [Access: April 25, 2024].

AMA (American Medical Association) Style

Ali S, Jamal T, Mushtaq A, Feroz S. Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. RMJ. 2024; 49(2): 427-430.


Vancouver/ICMJE Style

Ali S, Jamal T, Mushtaq A, Feroz S. Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. RMJ. (2024), [cited April 25, 2024]; 49(2): 427-430.


Harvard Style

Ali, S., Jamal, . T., Mushtaq, . A. & Feroz, . S. (2024) Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. RMJ, 49 (2), 427-430.


Turabian Style

Ali, Shazia, Tooba Jamal, Aysha Mushtaq, and Shagufta Feroz. 2024. Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. Rawal Medical Journal, 49 (2), 427-430.


Chicago Style

Ali, Shazia, Tooba Jamal, Aysha Mushtaq, and Shagufta Feroz. "Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats." Rawal Medical Journal 49 (2024), 427-430.


MLA (The Modern Language Association) Style

Ali, Shazia, Tooba Jamal, Aysha Mushtaq, and Shagufta Feroz. "Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats." Rawal Medical Journal 49.2 (2024), 427-430. Print.


APA (American Psychological Association) Style

Ali, S., Jamal, . T., Mushtaq, . A. & Feroz, . S. (2024) Impact of synbiotics on stress-induced alterations in cortisol levels and lipid profile in male Sprague Dawley Rats. Rawal Medical Journal, 49 (2), 427-430.


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