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Original Research 
RMJ. 2021; 46(2): 481-484


Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice

Farhat Humayun, Tabish Humayun, Nida Gulzar Zeb.

Abstract
Objective: To assess the disruption in the number of kupffer cells induced by isoniazid and role of propolis extract in male albino mice.
Methodology: This randomized Control Trial (RCT) was executed on healthy male albino mice, which were kept in animal house of University of Health Sciences, Lahore in 2012. Group I; received normal diet and fresh water orally. Group II; received normal diet, fresh water and isoniazid 100mg/kg body weight orally for 30 days. Group III, IV and V received 150 mg/kg body weight of propolis extract orally for 10 days, 20 and 30 days, respectively and isoniazid 100mg/kg b.w. orally for next 30 days. Kupffer cells were inclusively enumerated in H & E stained sections after calibrating ocular reticule with the help of light microscope.
Results: Group I showed the normal number of kupffer cells. Group II showed that remarkable kupffer cells hyperplasia which was significantly reduced in Group IV and V with increasing duration of administration of same dose of propolis.
Conclusion: Isoniazid is a hepatotoxic agent which is shown by kupffer cells hyperplasia in liver and Propolis decreased number of kupffer cells which showed its hepatoprotectivity.

Key words: Kupffer cells, hyperplasia, hepatotoxicity.


 
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How to Cite this Article
Pubmed Style

Humayun F, Humayun T, Zeb NG. Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. RMJ. 2021; 46(2): 481-484.


Web Style

Humayun F, Humayun T, Zeb NG. Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. http://www.rmj.org.pk/?mno=76209 [Access: June 12, 2021].


AMA (American Medical Association) Style

Humayun F, Humayun T, Zeb NG. Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. RMJ. 2021; 46(2): 481-484.



Vancouver/ICMJE Style

Humayun F, Humayun T, Zeb NG. Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. RMJ. (2021), [cited June 12, 2021]; 46(2): 481-484.



Harvard Style

Humayun, F., Humayun, . T. & Zeb, . N. G. (2021) Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. RMJ, 46 (2), 481-484.



Turabian Style

Humayun, Farhat, Tabish Humayun, and Nida Gulzar Zeb. 2021. Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. Rawal Medical Journal, 46 (2), 481-484.



Chicago Style

Humayun, Farhat, Tabish Humayun, and Nida Gulzar Zeb. "Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice." Rawal Medical Journal 46 (2021), 481-484.



MLA (The Modern Language Association) Style

Humayun, Farhat, Tabish Humayun, and Nida Gulzar Zeb. "Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice." Rawal Medical Journal 46.2 (2021), 481-484. Print.



APA (American Psychological Association) Style

Humayun, F., Humayun, . T. & Zeb, . N. G. (2021) Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice. Rawal Medical Journal, 46 (2), 481-484.








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