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Original Research 
RMJ. 2022; 47(2): 293-297


Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population

Shazia Nazar, Ambreen Qamar, Mirza Saifulla Baig, Fareeha Butt, Saqib Mohammad Ishaq, Akber Mughal.

Abstract
Objective: To determine the correlation of vitamin- D receptor protein (VDR) and vitamin-D with pre-diabetes.
Methodology: This case control study was conducted at Diabetes and Endocrine clinic of Dow University Hospital from August to December 2019. It included 160 subjects (80 pre-diabetics, 80 controls with mean age of 35.9±10.43, 34.72±12.10 years. The sample size was estimated using open-epi software. Serum vitamin D and VDR protein were determined using sandwich enzyme immunoassay (ELISA). Multi-variate regression analysis was done to evaluate the independent predictors for pre-diabetes. Data were analyzed on SPSS version 17.
Results: VDR protein (OR=1.013, 95% CI=1.024-1.041), IFG (OR=0.992, 95% CI=0.235-1.181), IGT (OR=0.911, 95% CI= 0.243-1.000) remained the strong independent predictor of pre-diabetes in logistic regression model adjusted for clinical and anthropometric parameters.
Conclusion: Vitamin D and VDR could be used as a screening marker and target for pre-diabetes. In the future, this could be used for diabetes mellitus prevention.

Key words: Vitamin-D, Vitamin-D receptor protein, pre-diabetes, normoglycemia.


 
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How to Cite this Article
Pubmed Style

Nazar S, Qamar A, Baig MS, Butt F, Ishaq SM, Mughal A. Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. RMJ. 2022; 47(2): 293-297.


Web Style

Nazar S, Qamar A, Baig MS, Butt F, Ishaq SM, Mughal A. Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. https://www.rmj.org.pk/?mno=70414 [Access: May 20, 2022].


AMA (American Medical Association) Style

Nazar S, Qamar A, Baig MS, Butt F, Ishaq SM, Mughal A. Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. RMJ. 2022; 47(2): 293-297.



Vancouver/ICMJE Style

Nazar S, Qamar A, Baig MS, Butt F, Ishaq SM, Mughal A. Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. RMJ. (2022), [cited May 20, 2022]; 47(2): 293-297.



Harvard Style

Nazar, S., Qamar, . A., Baig, . M. S., Butt, . F., Ishaq, . S. M. & Mughal, . A. (2022) Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. RMJ, 47 (2), 293-297.



Turabian Style

Nazar, Shazia, Ambreen Qamar, Mirza Saifulla Baig, Fareeha Butt, Saqib Mohammad Ishaq, and Akber Mughal. 2022. Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. Rawal Medical Journal, 47 (2), 293-297.



Chicago Style

Nazar, Shazia, Ambreen Qamar, Mirza Saifulla Baig, Fareeha Butt, Saqib Mohammad Ishaq, and Akber Mughal. "Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population." Rawal Medical Journal 47 (2022), 293-297.



MLA (The Modern Language Association) Style

Nazar, Shazia, Ambreen Qamar, Mirza Saifulla Baig, Fareeha Butt, Saqib Mohammad Ishaq, and Akber Mughal. "Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population." Rawal Medical Journal 47.2 (2022), 293-297. Print.



APA (American Psychological Association) Style

Nazar, S., Qamar, . A., Baig, . M. S., Butt, . F., Ishaq, . S. M. & Mughal, . A. (2022) Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population. Rawal Medical Journal, 47 (2), 293-297.








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