ISSN 0303-5212
 
2025, Vol: 50, Issue: 1
50 / 1Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_Certificate
Bank Reciept

Original Research 


Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia

Prastiya Indra Gunawan, Kartika Hardiyani, I Dewa Gede Ugrasena.


Abstract
Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool.
Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The inclusion criteria were Acute Lymphoblastic Leukemia (ALL) children aged 4-18 years that had undergone chemotherapy treatment, received a cumulative dose of vincristine >12 mg/m2, had no muscle weakness and signed informed consent. The TNS-PV instrument were used to assess VIPN and nerve conduction studies (NCS) was used as the gold standard.
Results: A total of 54 children were enrolled, two refused to sign the informed consent. About 60% were male children, 76.9% aged <10 years old, and 94% were ALL-L1. The TNS-PV had an area under the curve (AUC) of 0.638 (95% CI 0.531-0.834) with cut off value of 3.5. It had a sensitivity 87.9%; specificity 42.1%, positive predictive value 72.5%; negative predictive value (NPV) 66.6% and OR (Odds ratio) 5,273.
Conclusion: TNS-PV score cannot replace NCS as the gold standard, but TNS-PV can be an alternative tool for diagnosing VIPN.

Key words: Acute Lymphoblastic Leukemia, total neuropathy scale pediatric visncristine, vincristine induced peripheral neuropathy.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Prastiya Indra Gunawan
Articles by Kartika Hardiyani
Articles by I Dewa Gede Ugrasena
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. 2023; 48(1): 179-184. doi:10.5455/rmj20220613092311

Web Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. https://www.rmj.org.pk/?mno=57032 [Access: March 14, 2025]. doi:10.5455/rmj20220613092311

AMA (American Medical Association) Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. 2023; 48(1): 179-184. doi:10.5455/rmj20220613092311


Vancouver/ICMJE Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. (2023), [cited March 14, 2025]; 48(1): 179-184. doi:10.5455/rmj20220613092311


Harvard Style

Gunawan, P. I., Hardiyani, . K. & Ugrasena, . I. D. G. (2023) Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ, 48 (1), 179-184. doi:10.5455/rmj20220613092311


Turabian Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. 2023. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. Rawal Medical Journal, 48 (1), 179-184. doi:10.5455/rmj20220613092311


Chicago Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. "Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia." Rawal Medical Journal 48 (2023), 179-184. doi:10.5455/rmj20220613092311


MLA (The Modern Language Association) Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. "Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia." Rawal Medical Journal 48.1 (2023), 179-184. Print. doi:10.5455/rmj20220613092311


APA (American Psychological Association) Style

Gunawan, P. I., Hardiyani, . K. & Ugrasena, . I. D. G. (2023) Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. Rawal Medical Journal, 48 (1), 179-184. doi:10.5455/rmj20220613092311


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information