Abstract
Objective: To determine the efficacy of zinc therapy in male asthenospermia patients presented with infertility at PAEC hospital, Islamabad
Methodology: This descriptive study was conducted at Department of Urology, PAEC hospital, Islamabad from May 2015 to November 2015. WHO calculator was utilized for sample size calculation and Non probability sampling was used. Married males, age-18-50 years and lab findings showing asthenospermia were included in the study. Patients were provided with 20 mg zinc sulphate (per day) for time period of 3 months. Semen analysis was done for pre and post treatment sperm motility. Data were analyzed in SPSS. Comparison was done with independent t test and association was measured with Chi-square test. P≤ 0.05 was considered significant.
Results: Total 90 infertile males were included in study. Mean age of patients was 33.09±4.93 years. Baseline percent sperm motility was 2.05±3.33 and after 3 months percent sperm motility was 26.76±12.9SD (t=8.827, df=88, p=0.0000). Efficacy of zinc therapy is significantly associated with marriage duration (p<0.05) and insignificantly associated with age (p>0.05)
Conclusion: Zinc supplementation is an effective, safe and feasible therapy for asthenospermic infertile males. It was associated with significant increase in sperm motility.

Key words: Asthenospermia, zinc supplementation, sperm motility.