Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications

Farrah  BILAL; Mudassar Iqbal  ARAIN; Ubed Ur Rehman; Abdullah  Dayo; Muhammad Ali  Ghoto; Ahsan Ali Memon

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RMJ. 2019; 44(3): 445-448

Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications

Farrah Bilal, Mudassar Iqbal Arain, Ubed Ur Rehman, Abdullah Dayo, Muhammad Ali Ghoto, Ahsan Ali Memon.

Abstract
Objective: To examine the antimicrobial therapy as prophylaxis and treatment of bacterial infection in liver diseases and its complications.
Methodology: This descriptive study was carried out at Liaquat University of medical and health sciences hospital Hyderabad, Pakistan from May to October 2018. Patients of liver cirrhosis with positive HCV antibodies, age from 16 to 70 years were included. Diagnosis of liver impairment was based on patients clinical features and laboratory tests which is documented in patients records. Purposive sampling technique was used to collect the data. Child Pugh classes are used to determine the severity and prognosis of disease.
Results: Out of 250 patients, 156(61.2%) were males and 48(38.8%) were females. 109(43.6%) belonged to Child Pugh Class C. Ascitic fluid analysis showed that 101(40.4%) samples were infected and 40.4% were culture positive. Escherichia coli was most frequent in 41(20.5%) organism. Most frequently ceftriaxone was prescribed intravenously in 121(48.4%) patients.
Conclusion: Bacterial peritonitis was widespread in liver disease. Ascites was a major problem and ascitic fluid culture showed E.coli as commonest causative agent of infections. Ceftriaxone was mostly used in them.

Key words: Bacterial peritonitis, Child Pugh class, prophylaxis, cirrhosis.

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How to Cite this Article

Pubmed Style

Bilal F, Arain MI, Rehman UU, Dayo A, Ghoto MA, Memon AA. Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications. RMJ. 2019; 44(3): 445-448.

Web Style

Bilal F, Arain MI, Rehman UU, Dayo A, Ghoto MA, Memon AA. Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications. https://www.rmj.org.pk/?mno=37759 [Access: October 30, 2025].

AMA (American Medical Association) Style

Bilal F, Arain MI, Rehman UU, Dayo A, Ghoto MA, Memon AA. Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications. RMJ. 2019; 44(3): 445-448.

Vancouver/ICMJE Style

Harvard Style

Bilal, F. . ., Arain, . M. I., Rehman, . U. U., Dayo, . A., Ghoto, . M. A. & Memon, . A. A. (2019) Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications. RMJ, 44 (3), 445-448.

Turabian Style

Bilal, Farrah , Mudassar Iqbal Arain, Ubed Ur Rehman, Abdullah Dayo, Muhammad Ali Ghoto, and Ahsan Ali Memon. 2019. Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications. Rawal Medical Journal, 44 (3), 445-448.

Chicago Style

Bilal, Farrah , Mudassar Iqbal Arain, Ubed Ur Rehman, Abdullah Dayo, Muhammad Ali Ghoto, and Ahsan Ali Memon. "Utilization of antimicrobial agents for prophylaxis and treatment of bacterial infection in liver diseases and its complications." Rawal Medical Journal 44 (2019), 445-448.

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