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Original Research 
RMJ. 2026; 51(3): 643-648


NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan

Muhammad Uzair, Nida Sadiq, Sabah Farhat, Misha Asif Tauni, Fizza Salman, Syeda Sadia Fatima.


Abstract
Objective: To explore associations between depressive symptoms, MetS, and selected genetic polymorphisms (NPY, PRL, Chemerin, MC4R) in the Pakistani population.
Methodology: This cross-sectional proof-of-concept study was conducted at Aga Khan University. Data collection included demographic assessments, depression screening using Beck's Depression Inventory (BDI), DSM V, and PHQ9. Genetic analysis was done through DNA extraction, conventional and tetra-arm PCR, and Sanger sequencing. Mutation analysis was conducted using the NCBI database. The Statistical analyses were applied using SPSS version 20. Student t-test was applied to assess differences in mean. Chi-square statistics were used for gene frequency. In all instances, p<0.05 was considered significant.
Results: Of the 164 participants included, 33% had MetS. Those with MetS and depression had higher body fat, elevated glucose levels, and lower HDL (p<0.05). Screening tools agreed on diagnosis regardless of MetS (k=0.88). The recessive allele in NPY was associated with depression, schizophrenia, and self-harm, while the heterozygous phenotype for Chemerin was more common in those with depression and comorbid MetS.
Conclusion: This pilot study suggests a possible association between metabolic syndrome, depressive symptoms, and selected SNPs. However, findings are exploratory and hypothesis-generating. Larger clinically validated longitudinal studies are required before drawing causal or clinical conclusions.

Key words: Depression, metabolic syndrome, prolactin, neuropeptide Y, chemerin.


 
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How to Cite this Article
Pubmed Style

Uzair M, Sadiq N, Farhat S, Tauni MA, Salman F, Fatima SS. NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. RMJ. 2026; 51(3): 643-648.

Web Style

Uzair M, Sadiq N, Farhat S, Tauni MA, Salman F, Fatima SS. NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. https://www.rmj.org.pk/?mno=286152 [Access: August 19, 2026].

AMA (American Medical Association) Style

Uzair M, Sadiq N, Farhat S, Tauni MA, Salman F, Fatima SS. NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. RMJ. 2026; 51(3): 643-648.


Vancouver/ICMJE Style

Uzair M, Sadiq N, Farhat S, Tauni MA, Salman F, Fatima SS. NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. RMJ. (2026), [cited August 19, 2026]; 51(3): 643-648.


Harvard Style

Uzair, M., Sadiq, . N., Farhat, . S., Tauni, . M. A., Salman, . F. & Fatima, . S. S. (2026) NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. RMJ, 51 (3), 643-648.


Turabian Style

Uzair, Muhammad, Nida Sadiq, Sabah Farhat, Misha Asif Tauni, Fizza Salman, and Syeda Sadia Fatima. 2026. NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. Rawal Medical Journal, 51 (3), 643-648.


Chicago Style

Uzair, Muhammad, Nida Sadiq, Sabah Farhat, Misha Asif Tauni, Fizza Salman, and Syeda Sadia Fatima. "NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan." Rawal Medical Journal 51 (2026), 643-648.


MLA (The Modern Language Association) Style

Uzair, Muhammad, Nida Sadiq, Sabah Farhat, Misha Asif Tauni, Fizza Salman, and Syeda Sadia Fatima. "NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan." Rawal Medical Journal 51.3 (2026), 643-648. Print.


APA (American Psychological Association) Style

Uzair, M., Sadiq, . N., Farhat, . S., Tauni, . M. A., Salman, . F. & Fatima, . S. S. (2026) NPY rs16147 and Chemerin rs17173608 Polymorphisms and their association with Metabolic Syndrome and Depression: A Pilot study from Pakistan. Rawal Medical Journal, 51 (3), 643-648.


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