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Original Research
Online Published: 11 Sep 2026
 
RMJ. 2026; 51(4): 1140-1144


Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model

Mahjabeen Fatima Qureshi, Khadija Qamar, Aqsa Zahid, Mehwish Abaid, Mewish Razzaq, Ayesha Fatima.


Abstract
Objective: To compare the histomorphological changes in the articular cartilage of osteoarthritic rat knees induced by monosodium iodoacetate and treated with platelet-rich plasma (PRP) and Leukocyte platelet-rich plasma (L-PRP).
Methodology: This experimental study was done at the Department of Anatomy, Army Medical College, Rawalpindi, from December 2019 to Oct 2020. Ninety male Sprague-Dawley rats (2-3 months old, free of joint deformities) were randomly assigned to three groups (n=30 per group). Group A, the disease control group, and experimental Groups B and C were given an intra-articular injection of 1 mg of monosodium iodoacetate in the right knee joint to induce osteoarthritis. After 2 weeks, Groups B and C were injected with intra-articular PRP and L-PRP, respectively. All rats were sacrificed 8 weeks after the commencement of the study. The Mankin score was used to assess the severity of osteoarthritis.
Results: The mean Mankin score for Group C was 7.30±0.21, which was higher than that of Group B (2.50±1.42) but considerably lower than that of Group A (9.13±1.42). 40% of animals in group A had shown large areas of severe damage (Grade 5), as compared to group B (Grade 2) and C (Grade 3-4).
Conclusion: We found the regenerative potential of PRP was greater than L-PRP.

Key words: L-PRP, PRP, osteoarthritis.


 
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How to Cite this Article
Pubmed Style

Qureshi MF, Qamar K, Zahid A, Abaid M, Razzaq M, Fatima A. Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. RMJ. 2026; 51(4): 1140-1144.

Web Style

Qureshi MF, Qamar K, Zahid A, Abaid M, Razzaq M, Fatima A. Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. https://www.rmj.org.pk/?mno=282063 [Access: November 11, 2026].

AMA (American Medical Association) Style

Qureshi MF, Qamar K, Zahid A, Abaid M, Razzaq M, Fatima A. Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. RMJ. 2026; 51(4): 1140-1144.


Vancouver/ICMJE Style

Qureshi MF, Qamar K, Zahid A, Abaid M, Razzaq M, Fatima A. Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. RMJ. (2026), [cited November 11, 2026]; 51(4): 1140-1144.


Harvard Style

Qureshi, M. F., Qamar, . K., Zahid, . A., Abaid, . M., Razzaq, . M. & Fatima, . A. (2026) Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. RMJ, 51 (4), 1140-1144.


Turabian Style

Qureshi, Mahjabeen Fatima, Khadija Qamar, Aqsa Zahid, Mehwish Abaid, Mewish Razzaq, and Ayesha Fatima. 2026. Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. Rawal Medical Journal, 51 (4), 1140-1144.


Chicago Style

Qureshi, Mahjabeen Fatima, Khadija Qamar, Aqsa Zahid, Mehwish Abaid, Mewish Razzaq, and Ayesha Fatima. "Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model." Rawal Medical Journal 51 (2026), 1140-1144.


MLA (The Modern Language Association) Style

Qureshi, Mahjabeen Fatima, Khadija Qamar, Aqsa Zahid, Mehwish Abaid, Mewish Razzaq, and Ayesha Fatima. "Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model." Rawal Medical Journal 51.4 (2026), 1140-1144. Print.


APA (American Psychological Association) Style

Qureshi, M. F., Qamar, . K., Zahid, . A., Abaid, . M., Razzaq, . M. & Fatima, . A. (2026) Histomorphological evaluation of the therapeutic efficacy of intra-articular platelet-rich plasma with Leukocyte and platelet-rich plasma in osteoarthritic rat model. Rawal Medical Journal, 51 (4), 1140-1144.



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