ISSN 0303-5212
 
2025, Vol: 50, Issue: 4
50 / 4Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_Certificate
Bank Reciept

Review Article 


Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials

Darmadi Darmadi, Herwindo Ahmad, Cennikon Pakpahan, Sem Samuel Surja.


Abstract
Objective: This meta-analysis evaluates its efficacy and safety of Vericiguat, an oral soluble guanylate cyclase stimulator
Methodology: A systematic search was conducted using PubMed, Scopus, and Cochrane databases through May 31, 2024. Randomized controlled trials (RCTs) comparing vericiguat to placebo in heart failure patients were included. Pooled risk ratios (RR) for cardiovascular death, heart failure hospitalization, and adverse events were calculated using a fixed-effects model. Risk of bias was assessed using the Cochrane ROB 2.0 tool.
Results: Four RCTs comprising 3,564 patients were included, with overall low to unclear risk of bias. Vericiguat showed no statistically significant reduction in cardiovascular death (RR 0.90; 95% CI 0.75–1.07; p=0.23) or heart failure hospitalization (RR 0.92; 95% CI 0.85–1.01; p=0.06). Adverse event rates were similar between groups (RR 1.00; 95% CI 0.98–1.03; p=0.86).
Conclusion: Vericiguat appears to be a well-tolerated treatment for heart failure; however, current evidence does not confirm significant clinical benefit in reducing cardiovascular death or hospitalizations. Further large-scale trials are warranted to clarify its therapeutic role.

Key words: Vericiguat, placebo, heart failure, efficacy, safety.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Darmadi Darmadi
Articles by Herwindo Ahmad
Articles by Cennikon Pakpahan
Articles by Sem Samuel Surja
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Darmadi D, Ahmad H, Pakpahan C, Surja SS. Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. RMJ. 2025; 50(3): 825-830. doi:10.5455/rmj.20241215082320

Web Style

Darmadi D, Ahmad H, Pakpahan C, Surja SS. Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. https://www.rmj.org.pk/?mno=233030 [Access: October 30, 2025]. doi:10.5455/rmj.20241215082320

AMA (American Medical Association) Style

Darmadi D, Ahmad H, Pakpahan C, Surja SS. Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. RMJ. 2025; 50(3): 825-830. doi:10.5455/rmj.20241215082320


Vancouver/ICMJE Style

Darmadi D, Ahmad H, Pakpahan C, Surja SS. Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. RMJ. (2025), [cited October 30, 2025]; 50(3): 825-830. doi:10.5455/rmj.20241215082320


Harvard Style

Darmadi, D., Ahmad, . H., Pakpahan, . C. & Surja, . S. S. (2025) Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. RMJ, 50 (3), 825-830. doi:10.5455/rmj.20241215082320


Turabian Style

Darmadi, Darmadi, Herwindo Ahmad, Cennikon Pakpahan, and Sem Samuel Surja. 2025. Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. Rawal Medical Journal, 50 (3), 825-830. doi:10.5455/rmj.20241215082320


Chicago Style

Darmadi, Darmadi, Herwindo Ahmad, Cennikon Pakpahan, and Sem Samuel Surja. "Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials." Rawal Medical Journal 50 (2025), 825-830. doi:10.5455/rmj.20241215082320


MLA (The Modern Language Association) Style

Darmadi, Darmadi, Herwindo Ahmad, Cennikon Pakpahan, and Sem Samuel Surja. "Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials." Rawal Medical Journal 50.3 (2025), 825-830. Print. doi:10.5455/rmj.20241215082320


APA (American Psychological Association) Style

Darmadi, D., Ahmad, . H., Pakpahan, . C. & Surja, . S. S. (2025) Efficacy of Vericiguat in patients with heart failure: A systematic review and meta- analysis of randomized controlled trials. Rawal Medical Journal, 50 (3), 825-830. doi:10.5455/rmj.20241215082320


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information