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Original Research 
RMJ. 2022; 47(4): 857-859


Cassia senna for iron overload

Uzma Naeem, Muneeba Razzaq, Nighat Arif, Rabia Azhar, Maryam Naeem, Nazir Awan.

Abstract
Objective: To determine the effects of Cassia Senna on iron overloaded mice.
Methodology: This experimental randomized controlled trial was conducted in the multidisciplinary laboratory of the Zoology Department, Government College University, Lahore for six months period. Thirty-six male albino mice were divided into three groups, 12 in each group. Group one was a control group while iron overload was achieved in groups 2 and 3 by injections of iron dextran 0.1 ml/g bodyweight for 15 days. After confirmation of iron overload, only group 3 mice were allowed to feed on Cassia Senna (100 mg/Kg body weight) for further 15 days. Blood sampling was done on days 0, 15, and 30. On day 30 animals were sacrificed and organs were preserved to evaluate iron levels. Data were analyzed using Student’s t-test on SPSS version 22.
Results: The exogenous administration of iron in mice increased the iron levels in serum, liver, heart, and kidneys to a substantial level (p<0.05), Cassia Senna significantly decreased iron levels in these tissues (p<0.05).
Conclusion: Cassia Senna significantly decreased the iron levels in serum, kidney, liver, and heart of iron overloaded mice. The addition of Cassia Senna in patients suffering from complications due to iron overload, as an adjunct therapy can decrease the damaging effects of iron overload. So, clinical trials should be conducted to confirm its efficacy.

Key words: Iron overload, organ damage, Cassia Senna.


 
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How to Cite this Article
Pubmed Style

Naeem U, Razzaq M, Arif N, Azhar R, Naeem M, Awan N. Cassia senna for iron overload. RMJ. 2022; 47(4): 857-859.


Web Style

Naeem U, Razzaq M, Arif N, Azhar R, Naeem M, Awan N. Cassia senna for iron overload. https://www.rmj.org.pk/?mno=22982 [Access: November 12, 2022].


AMA (American Medical Association) Style

Naeem U, Razzaq M, Arif N, Azhar R, Naeem M, Awan N. Cassia senna for iron overload. RMJ. 2022; 47(4): 857-859.



Vancouver/ICMJE Style

Naeem U, Razzaq M, Arif N, Azhar R, Naeem M, Awan N. Cassia senna for iron overload. RMJ. (2022), [cited November 12, 2022]; 47(4): 857-859.



Harvard Style

Naeem, U., Razzaq, . M., Arif, . N., Azhar, . R., Naeem, . M. & Awan, . N. (2022) Cassia senna for iron overload. RMJ, 47 (4), 857-859.



Turabian Style

Naeem, Uzma, Muneeba Razzaq, Nighat Arif, Rabia Azhar, Maryam Naeem, and Nazir Awan. 2022. Cassia senna for iron overload. Rawal Medical Journal, 47 (4), 857-859.



Chicago Style

Naeem, Uzma, Muneeba Razzaq, Nighat Arif, Rabia Azhar, Maryam Naeem, and Nazir Awan. "Cassia senna for iron overload." Rawal Medical Journal 47 (2022), 857-859.



MLA (The Modern Language Association) Style

Naeem, Uzma, Muneeba Razzaq, Nighat Arif, Rabia Azhar, Maryam Naeem, and Nazir Awan. "Cassia senna for iron overload." Rawal Medical Journal 47.4 (2022), 857-859. Print.



APA (American Psychological Association) Style

Naeem, U., Razzaq, . M., Arif, . N., Azhar, . R., Naeem, . M. & Awan, . N. (2022) Cassia senna for iron overload. Rawal Medical Journal, 47 (4), 857-859.








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