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2025, Vol: 50, Issue: 1
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Review Article 


Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research

Herwindo Ahmad, Darmadi Darmadi, Maggie Liberty.


Abstract
Objective: To provide a comprehensive overview of bempedoic acid and ezetimibe combination therapy, including its mechanism of action, recent evidence on its benefits and safety, and future potential as a new cardioprotective therapy, particularly in high CVD risk patients.
Methodology: Literature search was performed on 3 search engines: PubMed/MEDLINE, ScienceDirect, and Cochrane Library. The included studies were assessed for the quality of study methods and reported data. Data were synthesized narratively, summarizing and discussing various research findings of combination therapy.
Conclusion: Bempedoic acid and ezetimibe combination therapy had a potential advantage in reducing CVD risk. Several simulation studies predicted that the cardioprotective effects of bempedoic acid and ezetimibe FDC therapy would advance the monotherapies.

Key words: Bempedoic acid, ezetimibe, LDL-cholesterol, hypercholesterolemia, cardiovascular diseases.


 
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How to Cite this Article
Pubmed Style

Ahmad H, Darmadi D, Liberty M. Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. RMJ. 2025; 50(1): 216-221. doi:10.5455/rmj.20241104095850

Web Style

Ahmad H, Darmadi D, Liberty M. Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. https://www.rmj.org.pk/?mno=227311 [Access: March 12, 2025]. doi:10.5455/rmj.20241104095850

AMA (American Medical Association) Style

Ahmad H, Darmadi D, Liberty M. Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. RMJ. 2025; 50(1): 216-221. doi:10.5455/rmj.20241104095850


Vancouver/ICMJE Style

Ahmad H, Darmadi D, Liberty M. Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. RMJ. (2025), [cited March 12, 2025]; 50(1): 216-221. doi:10.5455/rmj.20241104095850


Harvard Style

Ahmad, H., Darmadi, . D. & Liberty, . M. (2025) Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. RMJ, 50 (1), 216-221. doi:10.5455/rmj.20241104095850


Turabian Style

Ahmad, Herwindo, Darmadi Darmadi, and Maggie Liberty. 2025. Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. Rawal Medical Journal, 50 (1), 216-221. doi:10.5455/rmj.20241104095850


Chicago Style

Ahmad, Herwindo, Darmadi Darmadi, and Maggie Liberty. "Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research." Rawal Medical Journal 50 (2025), 216-221. doi:10.5455/rmj.20241104095850


MLA (The Modern Language Association) Style

Ahmad, Herwindo, Darmadi Darmadi, and Maggie Liberty. "Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research." Rawal Medical Journal 50.1 (2025), 216-221. Print. doi:10.5455/rmj.20241104095850


APA (American Psychological Association) Style

Ahmad, H., Darmadi, . D. & Liberty, . M. (2025) Bempedoic acid and ezetimibe combination therapy in patients with high cardiovascular Disease risk: A narrative review of current research. Rawal Medical Journal, 50 (1), 216-221. doi:10.5455/rmj.20241104095850


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