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Original Research 
RMJ. 2024; 49(4): 803-806


Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells

Durga Devi, Sabahat Fatima, Gulshad Wagan, Um-A- Aima, Fahad Sarfraz, Haseeb Khaliq.


Abstract
Objective: To determine Eugenol’s anti-cancer potential in Chronic Myeloid Leukemia concentrating at anti-proliferative effects on human leukemia HL-60 cells.
Methodology: This study included culturing HL-60 cells in pre-formulated commercially available Dulbecco's Modified Eagle Medium (DMEM) for HL-60 cell line and its treatment with serial concentrations of Eugenol for calculation of subsequent IC50 values via MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. Anti-proliferative activity was confirmed via Nitric Oxide (NO) releasing Assay.
Results: For HL-60 cells, the IC50 of Eugenol (10.1uM) showed persistent peaks of NO levels confirming its anti-proliferative potential. Strongest growth inhibitory activity was seen in the peak time of 100-120 min.
Conclusion: Eugenol was a strong anti-proliferative phytochemical agent leading to therapeutic effects against HL-60 cells. Further studies would help in identifying key molecular intricacies by which Eugenol exhibits diversified Anti-cancer potential.

Key words: Eugenol, Pro-apoptotic effects, anti-cancer mechanisms, HL-60 cells, natural chemotherapeutics.


 
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How to Cite this Article
Pubmed Style

Devi D, Fatima S, Wagan G, Aima U, Sarfraz F, Khaliq H. Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. RMJ. 2024; 49(4): 803-806.

Web Style

Devi D, Fatima S, Wagan G, Aima U, Sarfraz F, Khaliq H. Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. https://www.rmj.org.pk/?mno=217265 [Access: November 17, 2024].

AMA (American Medical Association) Style

Devi D, Fatima S, Wagan G, Aima U, Sarfraz F, Khaliq H. Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. RMJ. 2024; 49(4): 803-806.


Vancouver/ICMJE Style

Devi D, Fatima S, Wagan G, Aima U, Sarfraz F, Khaliq H. Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. RMJ. (2024), [cited November 17, 2024]; 49(4): 803-806.


Harvard Style

Devi, D., Fatima, . S., Wagan, . G., Aima, . U., Sarfraz, . F. & Khaliq, . H. (2024) Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. RMJ, 49 (4), 803-806.


Turabian Style

Devi, Durga, Sabahat Fatima, Gulshad Wagan, Um-A- Aima, Fahad Sarfraz, and Haseeb Khaliq. 2024. Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. Rawal Medical Journal, 49 (4), 803-806.


Chicago Style

Devi, Durga, Sabahat Fatima, Gulshad Wagan, Um-A- Aima, Fahad Sarfraz, and Haseeb Khaliq. "Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells." Rawal Medical Journal 49 (2024), 803-806.


MLA (The Modern Language Association) Style

Devi, Durga, Sabahat Fatima, Gulshad Wagan, Um-A- Aima, Fahad Sarfraz, and Haseeb Khaliq. "Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells." Rawal Medical Journal 49.4 (2024), 803-806. Print.


APA (American Psychological Association) Style

Devi, D., Fatima, . S., Wagan, . G., Aima, . U., Sarfraz, . F. & Khaliq, . H. (2024) Eugenol's anti-proliferative therapeutic potential for leukemia pathology; Insights from HL-60 cells. Rawal Medical Journal, 49 (4), 803-806.


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