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Original Research 
RMJ. 2024; 49(4): 746-749


Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy

Durga Devi, Moeed Ullah Khan, Naeemullah Syed, Zain ul Abden Bilal Ahmed, Abdul Munim, Ehsan Khan.


Abstract
Objective: To investigate the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in managing diabetic retinopathy (DR) by exploring its neuroprotective effects on retinal cells and its ability to mitigate disease progression.
Methodology: This study involved 150 subjects (68 male, 82 female) including 34 healthy controls and 116 patients with DR, enrolled from OPDs and clinical care settings with mean age of 53±6.7 years. Plasma samples were subjected to Enzyme linked Immunosorbent Assay for the determination of GDNF levels. HbA1c (%) and Fasting Glucose levels (mmol/L) were used as confounders. Statistical analyses were done via SPSS 26 (T-test, significance value p<0.05).
Results: Mean GDNF level in the DR patients (4.60±2.06 µg/ml) was found significantly lower as compared to healthy controls (12.50±4.64 µg/ml) indicating that lower GDNF levels are associated with DR. HbA1c (%) and Fasting glucose were 10.49±1.12 (%) and 8.03±0.52 (mmol/L), respectively.
Conclusion: Lower GDNF levels were associated with DR, highlighting its pathological role, and confirming GDNF recovery levels as a therapeutic target to DR.

Key words: Diabetic rretinopathy, neuropathology, Glial cell-derived neurotrophic factor.


 
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How to Cite this Article
Pubmed Style

Devi D, Khan MU, Syed N, Ahmed ZuAB, Munim A, Khan E. Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. RMJ. 2024; 49(4): 746-749.

Web Style

Devi D, Khan MU, Syed N, Ahmed ZuAB, Munim A, Khan E. Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. https://www.rmj.org.pk/?mno=215929 [Access: November 16, 2024].

AMA (American Medical Association) Style

Devi D, Khan MU, Syed N, Ahmed ZuAB, Munim A, Khan E. Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. RMJ. 2024; 49(4): 746-749.


Vancouver/ICMJE Style

Devi D, Khan MU, Syed N, Ahmed ZuAB, Munim A, Khan E. Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. RMJ. (2024), [cited November 16, 2024]; 49(4): 746-749.


Harvard Style

Devi, D., Khan, . M. U., Syed, . N., Ahmed, . Z. u. A. B., Munim, . A. & Khan, . E. (2024) Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. RMJ, 49 (4), 746-749.


Turabian Style

Devi, Durga, Moeed Ullah Khan, Naeemullah Syed, Zain ul Abden Bilal Ahmed, Abdul Munim, and Ehsan Khan. 2024. Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. Rawal Medical Journal, 49 (4), 746-749.


Chicago Style

Devi, Durga, Moeed Ullah Khan, Naeemullah Syed, Zain ul Abden Bilal Ahmed, Abdul Munim, and Ehsan Khan. "Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy." Rawal Medical Journal 49 (2024), 746-749.


MLA (The Modern Language Association) Style

Devi, Durga, Moeed Ullah Khan, Naeemullah Syed, Zain ul Abden Bilal Ahmed, Abdul Munim, and Ehsan Khan. "Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy." Rawal Medical Journal 49.4 (2024), 746-749. Print.


APA (American Psychological Association) Style

Devi, D., Khan, . M. U., Syed, . N., Ahmed, . Z. u. A. B., Munim, . A. & Khan, . E. (2024) Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy. Rawal Medical Journal, 49 (4), 746-749.


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