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2024, Vol: 49, Issue: 4
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Original Research 


Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection

Ade Dharmawan, Pusparini Pusparini.


Abstract
Objective: To determine the association of Fecal Calprotectin (f-CP) and M2 Pyruvate Kinase (M2-PK) with intestinal pathogens by means of the gastrointestinal syndromic panel.
Methodology: This retrospective analytic study was conducted in the laboratory department a private hospital in Jakarta from October 2021 to September 2022. The inclusion criteria comprised patients aged ≥18 years with gastrointestinal complaints who had undergone f-CP and M2-PK examinations and gastrointestinal syndromic testing. The exclusion criteria were incomplete data on laboratory examinations, follow-up examinations or treatment evaluations. We used the Mann-Whitney test with p<0.05 indicating significantly different.
Results: Out of 282 subjects, 69% were women and 31% men, aged 18 to 84 years (mean 50.52±15.20). In 117 subjects, single pathogen was found in 78 specimens and ≥2 pathogens in 39. Median f-CP was 77.1 µg/g (3.68-2100) and median M2-PK 3.55 U/mL (1-72.6). Mann-Whitney test found a significant association between f-CP and intestinal pathogens (p=0.048), whereas for the M2-PK, no significant association was found with intestinal pathogens a(p=0.381).
Conclusion: f-CP increases in gastrointestinal infection with intestinal pathogens, but M2-PK does not increase. Therefore, f-CP can be considered a biomarker for gastrointestinal infections caused by microorganisms.

Key words: Fecal calprotectin, GI-syndromic testing, gastrointestinal infection, M2-PK.


 
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How to Cite this Article
Pubmed Style

Dharmawan A, Pusparini P. Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. RMJ. 2024; 49(4): 754-758. doi:10.5455/rmj.20240812023946

Web Style

Dharmawan A, Pusparini P. Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. https://www.rmj.org.pk/?mno=215320 [Access: November 17, 2024]. doi:10.5455/rmj.20240812023946

AMA (American Medical Association) Style

Dharmawan A, Pusparini P. Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. RMJ. 2024; 49(4): 754-758. doi:10.5455/rmj.20240812023946


Vancouver/ICMJE Style

Dharmawan A, Pusparini P. Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. RMJ. (2024), [cited November 17, 2024]; 49(4): 754-758. doi:10.5455/rmj.20240812023946


Harvard Style

Dharmawan, A. & Pusparini, . P. (2024) Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. RMJ, 49 (4), 754-758. doi:10.5455/rmj.20240812023946


Turabian Style

Dharmawan, Ade, and Pusparini Pusparini. 2024. Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. Rawal Medical Journal, 49 (4), 754-758. doi:10.5455/rmj.20240812023946


Chicago Style

Dharmawan, Ade, and Pusparini Pusparini. "Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection." Rawal Medical Journal 49 (2024), 754-758. doi:10.5455/rmj.20240812023946


MLA (The Modern Language Association) Style

Dharmawan, Ade, and Pusparini Pusparini. "Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection." Rawal Medical Journal 49.4 (2024), 754-758. Print. doi:10.5455/rmj.20240812023946


APA (American Psychological Association) Style

Dharmawan, A. & Pusparini, . P. (2024) Association of fecal calprotectin and M2 pyruvate kinase with fecal pathogenic microorganisms in gastrointestinal infection. Rawal Medical Journal, 49 (4), 754-758. doi:10.5455/rmj.20240812023946


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