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Original Research
Online Published: 03 Nov 2015
 
RMJ. 2015; 40(4): 379-382


Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience

Syed Sajid Hussain Shah, Naureen Akhtar, Faiza Sunbleen.


Abstract
Objective: To observe the response and adverse effects of cyclosporine in combination with oral steroids for management of idiopathic steroid resistant nephrotic syndrome in pediatric patients.
Methodology: It was an observational study conducted at Children’s Hospital, Lahore, Pakistan from March 2014 to June 2015. Forty normotensive patients of idiopathic steroid resistant nephrotic syndrome between one and twelve years of age with normal renal function were included in the study. Patients were prescribed cyclosporine with prednisolone and were followed to see the response and adverse effects of drugs.
Results: Out of 40 patients, 20(50%) were males and 20(50%) females. Mesangioproliferative glomerulonephritis was found in 27(67.5%) patients followed by Focal segmental glomerulosclerosis in 9(22.5%) patients. Complete response was observed in 32(80%) children while partial response in 8(20%) patients at the end of six months. The most common adverse effects were cushingoid features seen in 26(65%) and cyclosporine related hypertrichosis in 34(85%).
Conclusion: Management of idiopathic steroid resistant nephrotic syndrome in children with a combination of cyclosporine and prednisolone provided good results as response to treatment was seen in 80% patients.

Key words: Steroid resistant, mesangioproliferative glomerulonephritis, focal segmental glomerulosclerosis, cyclosporine, nephrotic syndrome  


 
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How to Cite this Article
Pubmed Style

Shah SSH, Akhtar N, Sunbleen F. Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. RMJ. 2015; 40(4): 379-382.

Web Style

Shah SSH, Akhtar N, Sunbleen F. Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. https://www.rmj.org.pk/?mno=197406 [Access: October 30, 2025].

AMA (American Medical Association) Style

Shah SSH, Akhtar N, Sunbleen F. Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. RMJ. 2015; 40(4): 379-382.


Vancouver/ICMJE Style

Shah SSH, Akhtar N, Sunbleen F. Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. RMJ. (2015), [cited October 30, 2025]; 40(4): 379-382.


Harvard Style

Shah, S. S. H., Akhtar, . N. & Sunbleen, . F. (2015) Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. RMJ, 40 (4), 379-382.


Turabian Style

Shah, Syed Sajid Hussain, Naureen Akhtar, and Faiza Sunbleen. 2015. Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. Rawal Medical Journal, 40 (4), 379-382.


Chicago Style

Shah, Syed Sajid Hussain, Naureen Akhtar, and Faiza Sunbleen. "Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience." Rawal Medical Journal 40 (2015), 379-382.


MLA (The Modern Language Association) Style

Shah, Syed Sajid Hussain, Naureen Akhtar, and Faiza Sunbleen. "Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience." Rawal Medical Journal 40.4 (2015), 379-382. Print.


APA (American Psychological Association) Style

Shah, S. S. H., Akhtar, . N. & Sunbleen, . F. (2015) Management of steroid resistant nephrotic syndrome in children with cyclosporine - a tertiary care centre experience. Rawal Medical Journal, 40 (4), 379-382.


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