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Original Research 
RMJ. 2025; 50(2): 321-324


Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan

Ayesha Tariq, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, Irfan Ullah.


Abstract
Objective: To evaluate the efficacy of Fosfomycin and ciprofloxacin in the treatment of urinary tract infections (UTI) in pediatric patients.
Methodology: This study was carried out at Railway General Hospital's Pediatric Department, Rawalpindi and included 160 patients of UTI. Participants were randomly assigned to either Group A, where they received a 5-day oral course of ciprofloxacin, or Group B, where a single oral dose of Fosfomycin was administered.
Results: The average age in Group A was 5.2±2.0 years and in Group B was 6.7±2.5 years. Group A comprised 43 males (66.2%) and 22 females (33.8%). Group B consisted of 40 males (61.5%) and 25 females (438.5%). Ciprofloxacin demonstrated efficacy in 36 patients (55.4%) in Group A. Fosfomycin exhibited efficacy in 50 patients (76.9%) in Group B (p=0.016).
Conclusion: A single oral dose of Fosfomycin proved to be more efficacious than a 5-day regimen of oral ciprofloxacin in treating acute uncomplicated UTI in children.

Key words: Antimicrobial, children, resistance, uropathogens.


 
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How to Cite this Article
Pubmed Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ. 2025; 50(2): 321-324.

Web Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. https://www.rmj.org.pk/?mno=195088 [Access: May 12, 2025].

AMA (American Medical Association) Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ. 2025; 50(2): 321-324.


Vancouver/ICMJE Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ. (2025), [cited May 12, 2025]; 50(2): 321-324.


Harvard Style

Tariq, A., Shaikh, . S. A., Sattar, . H., Naeem, . M. M., Hussain, . A. & Ullah, . I. (2025) Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ, 50 (2), 321-324.


Turabian Style

Tariq, Ayesha, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, and Irfan Ullah. 2025. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. Rawal Medical Journal, 50 (2), 321-324.


Chicago Style

Tariq, Ayesha, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, and Irfan Ullah. "Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan." Rawal Medical Journal 50 (2025), 321-324.


MLA (The Modern Language Association) Style

Tariq, Ayesha, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, and Irfan Ullah. "Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan." Rawal Medical Journal 50.2 (2025), 321-324. Print.


APA (American Psychological Association) Style

Tariq, A., Shaikh, . S. A., Sattar, . H., Naeem, . M. M., Hussain, . A. & Ullah, . I. (2025) Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. Rawal Medical Journal, 50 (2), 321-324.


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