Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan

Ayesha Tariq; Saba Afzal Shaikh; Hina Sattar; Malik Muhammad Naeem; Arif Hussain; Irfan ullah

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RMJ. 2025; 50(2): 321-324

Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan

Ayesha Tariq, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, Irfan Ullah.

Abstract
Objective: To evaluate the efficacy of Fosfomycin and ciprofloxacin in the treatment of urinary tract infections (UTI) in pediatric patients.
Methodology: This study was carried out at Railway General Hospital's Pediatric Department, Rawalpindi and included 160 patients of UTI. Participants were randomly assigned to either Group A, where they received a 5-day oral course of ciprofloxacin, or Group B, where a single oral dose of Fosfomycin was administered.
Results: The average age in Group A was 5.2±2.0 years and in Group B was 6.7±2.5 years. Group A comprised 43 males (66.2%) and 22 females (33.8%). Group B consisted of 40 males (61.5%) and 25 females (438.5%). Ciprofloxacin demonstrated efficacy in 36 patients (55.4%) in Group A. Fosfomycin exhibited efficacy in 50 patients (76.9%) in Group B (p=0.016).
Conclusion: A single oral dose of Fosfomycin proved to be more efficacious than a 5-day regimen of oral ciprofloxacin in treating acute uncomplicated UTI in children.

Key words: Antimicrobial, children, resistance, uropathogens.

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How to Cite this Article

Pubmed Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ. 2025; 50(2): 321-324.

Web Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. https://www.rmj.org.pk/?mno=195088 [Access: October 30, 2025].

AMA (American Medical Association) Style

Tariq A, Shaikh SA, Sattar H, Naeem MM, Hussain A, Ullah I. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ. 2025; 50(2): 321-324.

Vancouver/ICMJE Style

Harvard Style

Tariq, A., Shaikh, . S. A., Sattar, . H., Naeem, . M. M., Hussain, . A. & Ullah, . I. (2025) Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. RMJ, 50 (2), 321-324.

Turabian Style

Tariq, Ayesha, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, and Irfan Ullah. 2025. Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan. Rawal Medical Journal, 50 (2), 321-324.

Chicago Style

Tariq, Ayesha, Saba Afzal Shaikh, Hina Sattar, Malik Muhammad Naeem, Arif Hussain, and Irfan Ullah. "Comparison of efficacy of fosfomycin with ciprofloxacin in paediatric uncomplicated UTI; A Randomized control trial in tertiary care hospitals of Pakistan." Rawal Medical Journal 50 (2025), 321-324.

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