ISSN 0303-5212
 

Original Research 
RMJ. 2024; 49(3): 502-507


Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study

Arsalan Shahid, Samia Perwaiz Khan, Rizwana Waraich, Safia Izhar.


Abstract
Objective: To determine the effect of different treatment modalities on health outcomes in patients with osteoporosis.
Methodology: The study was conducted at a Medicare Cardiac and General Hospital and used a longitudinal design to follow up on participants from the Orthopedic Outpatient Department who were aged 35-60 or older and diagnosed with osteoporosis based on their DEXA scan T score. At the baseline, demographic data, medical history, physical activity, joint discomfort, periodontal pocket, and clinical attachment level were recorded. Intravenous bisphosphonate of 3 mg every 3 months, subcutaneous denosumab of 60mg every 6 months, along with calcium supplements (1200 mg/day) and vitamin D (600 IU/day) were administered. After a 1-year follow-up, the outcome variables were measured and compared to the baseline. The statistical analysis was performed using SPSS software and paired T-tests, and the Fischer exact test were used.
Results: The study included 200 participants, with mean age of 61.36±10.42 years and a mean BMI of 31.58±16.52. After 12 months of therapy, significant differences were observed in physical health outcomes, with the bisphosphonate group showing superior results in joint discomfort and physical activity compared to the denosumab group (p<0.001). Moreover, the bisphosphonate group demonstrated significantly higher clinical attachment level and shallower periodontal pocket depth, suggesting potential improvement in periodontal health (p<0.001).
Conclusion: Bisphosphonate treatment may be more effective than denosumab in reducing joint pain, overall health, and periodontal health in individuals with osteoporosis, underscoring the importance of personalized treatment strategies in clinical practice.

Key words: DEXA, osteoporosis. bisphosphonate, denosumab, physical & periodontal health.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Arsalan Shahid
Articles by Samia Perwaiz Khan
Articles by Rizwana Waraich
Articles by Safia Izhar
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Shahid A, Khan SP, Waraich R, Izhar S. Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. RMJ. 2024; 49(3): 502-507.


Web Style

Shahid A, Khan SP, Waraich R, Izhar S. Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. https://www.rmj.org.pk/?mno=193515 [Access: November 17, 2024].


AMA (American Medical Association) Style

Shahid A, Khan SP, Waraich R, Izhar S. Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. RMJ. 2024; 49(3): 502-507.



Vancouver/ICMJE Style

Shahid A, Khan SP, Waraich R, Izhar S. Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. RMJ. (2024), [cited November 17, 2024]; 49(3): 502-507.



Harvard Style

Shahid, A., Khan, . S. P., Waraich, . R. & Izhar, . S. (2024) Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. RMJ, 49 (3), 502-507.



Turabian Style

Shahid, Arsalan, Samia Perwaiz Khan, Rizwana Waraich, and Safia Izhar. 2024. Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. Rawal Medical Journal, 49 (3), 502-507.



Chicago Style

Shahid, Arsalan, Samia Perwaiz Khan, Rizwana Waraich, and Safia Izhar. "Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study." Rawal Medical Journal 49 (2024), 502-507.



MLA (The Modern Language Association) Style

Shahid, Arsalan, Samia Perwaiz Khan, Rizwana Waraich, and Safia Izhar. "Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study." Rawal Medical Journal 49.3 (2024), 502-507. Print.



APA (American Psychological Association) Style

Shahid, A., Khan, . S. P., Waraich, . R. & Izhar, . S. (2024) Exploring the effect of different treatment modalities on health outcome in osteoporosis; A follow-up study. Rawal Medical Journal, 49 (3), 502-507.