ISSN 0303-5212
 
2025, Vol: 50, Issue: 1
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Original Research 


Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis

Shabana Ali, Tayyaba Qureshi.


Abstract
Objective: To determine the synergistic effects of Coenzyme Q10 and L-Carnitine for an enhanced peripheral remyelination in multiple sclerosis.
Methodology: This study used 50 rats divided into 5 groups. Group 1 received standard rodent pellet chow for 12 weeks and Groups 2 to 5 received standard rodent pellet chow mixed with 0.2% Cuprizone (CPZ) or 12 weeks. Groups 3 and 4 were administered 150 mg/kg/day CoQ10 and 100 mg/kg/day L-Carnitine respectively from the 4th week, while Group 5 was given a combination of both agents. After 12 weeks, rats were dissected, and sections of sciatic nerve were stained with H& E for schwann cell and axonal count. Toludine blue was used for myelin sheath thickness, and intensity of staining of myelin sheath was checked using Luxol fast blue. Immunohistochemistry was performed using BCl2 antibodies, and intensity of staining was used to compare groups.
Results: Myelin sheath thickness, intensity of staining of myelin sheath, Schwann cell count and axonal count improved significantly by the combination of CoQ10 & L-Car as compared to the individual agent. Immunohistochemistry also suggested better control of apoptosis by synergistic group.
Conclusion: The study provided histological evidence of

Key words: Coenzyme Q10, L-Carnitine, multiple sclerosis, peripheral remyelination.


 
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How to Cite this Article
Pubmed Style

Ali S, Qureshi T. Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. RMJ. 2025; 50(1): 34-37.

Web Style

Ali S, Qureshi T. Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. https://www.rmj.org.pk/?mno=192329 [Access: March 12, 2025].

AMA (American Medical Association) Style

Ali S, Qureshi T. Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. RMJ. 2025; 50(1): 34-37.


Vancouver/ICMJE Style

Ali S, Qureshi T. Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. RMJ. (2025), [cited March 12, 2025]; 50(1): 34-37.


Harvard Style

Ali, S. & Qureshi, . T. (2025) Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. RMJ, 50 (1), 34-37.


Turabian Style

Ali, Shabana, and Tayyaba Qureshi. 2025. Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. Rawal Medical Journal, 50 (1), 34-37.


Chicago Style

Ali, Shabana, and Tayyaba Qureshi. "Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis." Rawal Medical Journal 50 (2025), 34-37.


MLA (The Modern Language Association) Style

Ali, Shabana, and Tayyaba Qureshi. "Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis." Rawal Medical Journal 50.1 (2025), 34-37. Print.


APA (American Psychological Association) Style

Ali, S. & Qureshi, . T. (2025) Synergistic effects of Coenzyme Q10 & L-Carnitine on peripheral remyelination in rat model of Multiple Sclerosis. Rawal Medical Journal, 50 (1), 34-37.


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