ISSN 0303-5212
 

Editorial 


PPI safety concerns

Nasir Khokhar.

Abstract
Proton Pump Inhibitors (PPIs) are among the most prescribed therapeutic agents worldwide. Their role in management of acid related disorders and in critically ill patients at risk for the development of stress related mucosal bleeding is well established.1 However, reports on their safety have appeared recently. Hypochlorhydria, hypergastrinemia, interactions on hepatic cytochrome P450 enzymes, nutritional deficiencies, anemia, osteoporosis and bone fractures (especially vertebral), increased risk for pulmonary or enteric infections, polyp or tumor formation and risk of cardiovascular events in patients on PPIs and clopidogrel have been recent highlighted concerns.2 While there is considerable debate regarding the negative impact of concomitant PPIs therapy with clopidogrel, platelet function studies did not demonstrate a clear or consistent interaction between clopidogrel and PPIs.3

Key words: PPI, osteoporosis, pneumonia


 
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Pubmed Style

Nasir Khokhar. PPI safety concerns . RMJ. 2012; 37(1): 1-1.


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Nasir Khokhar. PPI safety concerns . https://www.rmj.org.pk/?mno=16747 [Access: December 06, 2023].


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Nasir Khokhar. PPI safety concerns . RMJ. 2012; 37(1): 1-1.



Vancouver/ICMJE Style

Nasir Khokhar. PPI safety concerns . RMJ. (2012), [cited December 06, 2023]; 37(1): 1-1.



Harvard Style

Nasir Khokhar (2012) PPI safety concerns . RMJ, 37 (1), 1-1.



Turabian Style

Nasir Khokhar. 2012. PPI safety concerns . Rawal Medical Journal, 37 (1), 1-1.



Chicago Style

Nasir Khokhar. "PPI safety concerns ." Rawal Medical Journal 37 (2012), 1-1.



MLA (The Modern Language Association) Style

Nasir Khokhar. "PPI safety concerns ." Rawal Medical Journal 37.1 (2012), 1-1. Print.



APA (American Psychological Association) Style

Nasir Khokhar (2012) PPI safety concerns . Rawal Medical Journal, 37 (1), 1-1.