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Original Research 
RMJ. 2022; 47(2): 494-497


Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits

Shahid Ali, Uzma Ali, Mohammad Anwer Bangulzai, Hira Malik, Adnan Anwer, Muslim Abbas.

Abstract
Objective: To assess the hepatoprotective effects of Ivy leaf extract in order to overcome the hepatotoxicity induced by isoniazid in rabbits.
Methodology: This analytical experimental study was carried out at animal house in the Department of Pharmacology, Karachi University. The duration of the study was 60 days. A total of 30 healthy rabbits were divided randomly into three equal groups. Group I or control group, group II isoniazid (INH) group while in group III combined effects of isoniazid and Ivy leaf extract. Serum alanine transaminase (ALT) level was measured. ANOVA test followed by post hoc multiple comparison was applied to assess the difference between the groups.
Results: There was significant difference in the mean level of ALT at Day 7 between the groups (p=0.001). A significant difference was observed between the groups at day 30 and 60 (p<0.001). Multiple comparisons of ALT level at day 60 showed significant increase between group I and group II (p<0.001), significant difference was observed between group I and group III (p=0.042), whereas significant decreased was observed between group II and group III (p<0.001). Multiple comparisons of total bilirubin level at Day 60 in different groups revealed significantly increased level between group I and II (p<0.001) as well as between I and III (p=0.012) and between group II and III (p=0.002).
Conclusion: The oral administration of Ivy leaf extract produced a hepatoprotective effect in isoniazid induced liver injury by reducing the serum glutamate oxaloacetate transaminase level.

Key words: Hepatotoxicity, isoniazid, serum glutamate oxaloacetate transaminase, SGOT.


 
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How to Cite this Article
Pubmed Style

Ali S, Ali U, Bangulzai MA, Malik H, Anwer A, Abbas M. Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. RMJ. 2022; 47(2): 494-497.


Web Style

Ali S, Ali U, Bangulzai MA, Malik H, Anwer A, Abbas M. Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. https://www.rmj.org.pk/?mno=125751 [Access: May 20, 2022].


AMA (American Medical Association) Style

Ali S, Ali U, Bangulzai MA, Malik H, Anwer A, Abbas M. Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. RMJ. 2022; 47(2): 494-497.



Vancouver/ICMJE Style

Ali S, Ali U, Bangulzai MA, Malik H, Anwer A, Abbas M. Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. RMJ. (2022), [cited May 20, 2022]; 47(2): 494-497.



Harvard Style

Ali, S., Ali, . U., Bangulzai, . M. A., Malik, . H., Anwer, . A. & Abbas, . M. (2022) Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. RMJ, 47 (2), 494-497.



Turabian Style

Ali, Shahid, Uzma Ali, Mohammad Anwer Bangulzai, Hira Malik, Adnan Anwer, and Muslim Abbas. 2022. Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. Rawal Medical Journal, 47 (2), 494-497.



Chicago Style

Ali, Shahid, Uzma Ali, Mohammad Anwer Bangulzai, Hira Malik, Adnan Anwer, and Muslim Abbas. "Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits." Rawal Medical Journal 47 (2022), 494-497.



MLA (The Modern Language Association) Style

Ali, Shahid, Uzma Ali, Mohammad Anwer Bangulzai, Hira Malik, Adnan Anwer, and Muslim Abbas. "Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits." Rawal Medical Journal 47.2 (2022), 494-497. Print.



APA (American Psychological Association) Style

Ali, S., Ali, . U., Bangulzai, . M. A., Malik, . H., Anwer, . A. & Abbas, . M. (2022) Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits. Rawal Medical Journal, 47 (2), 494-497.








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