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Original Research 
RMJ. 2025; 50(3): 640-643


Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain

Faiza Firdous, Sarmad Arsalan, Sehrish Siddique, Rubina Shahzad, Gohar Rasheed, Jahangir Sarwar Khan.


Abstract
Objective: To compare 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain.
Methodology: This randomized controlled trial was conducted at General Surgery department, DHQ Teaching Hospital, Rawalpindi and included a total of 60 patients. These were divided randomly into two groups. Patients in both groups underwent standard open hemorrhoidectomy. Group A was treated with oral metronidazole 400 mg thrice a day and in group-B patients, 10% metronidazole paste was applied soon after surgery and thrice daily. Visual Analogue score was recorded daily by the patient for one week The outcome was noted in both groups. All data were analyzed on SPSS 21.
Results: The mean age was 45.25±11.64 years. Among group A patients the mean value of total average pain score was 6.86±0.79 whereas among group B patients, total average pain score was 5.96±0.956 (p<0.001).
Conclusion: The 10% topical metronidazole showed significantly better outcome than oral metronidazole in hemorrhoidectomy in terms of mean post-operative pain.

Key words: Oral Metronidazole, topical metronidazole, hemorrhoidectomy, post-operative pain.


 
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How to Cite this Article
Pubmed Style

Firdous F, Arsalan S, Siddique S, Shahzad R, Rasheed G, Khan JS. Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. RMJ. 2025; 50(3): 640-643.

Web Style

Firdous F, Arsalan S, Siddique S, Shahzad R, Rasheed G, Khan JS. Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. https://www.rmj.org.pk/?mno=120250 [Access: October 30, 2025].

AMA (American Medical Association) Style

Firdous F, Arsalan S, Siddique S, Shahzad R, Rasheed G, Khan JS. Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. RMJ. 2025; 50(3): 640-643.


Vancouver/ICMJE Style

Firdous F, Arsalan S, Siddique S, Shahzad R, Rasheed G, Khan JS. Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. RMJ. (2025), [cited October 30, 2025]; 50(3): 640-643.


Harvard Style

Firdous, F., Arsalan, . S., Siddique, . S., Shahzad, . R., Rasheed, . G. & Khan, . J. S. (2025) Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. RMJ, 50 (3), 640-643.


Turabian Style

Firdous, Faiza, Sarmad Arsalan, Sehrish Siddique, Rubina Shahzad, Gohar Rasheed, and Jahangir Sarwar Khan. 2025. Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. Rawal Medical Journal, 50 (3), 640-643.


Chicago Style

Firdous, Faiza, Sarmad Arsalan, Sehrish Siddique, Rubina Shahzad, Gohar Rasheed, and Jahangir Sarwar Khan. "Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain." Rawal Medical Journal 50 (2025), 640-643.


MLA (The Modern Language Association) Style

Firdous, Faiza, Sarmad Arsalan, Sehrish Siddique, Rubina Shahzad, Gohar Rasheed, and Jahangir Sarwar Khan. "Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain." Rawal Medical Journal 50.3 (2025), 640-643. Print.


APA (American Psychological Association) Style

Firdous, F., Arsalan, . S., Siddique, . S., Shahzad, . R., Rasheed, . G. & Khan, . J. S. (2025) Comparison of 10% topical metronidazole versus oral metronidazole in hemorrhoidectomy in terms of post-operative pain. Rawal Medical Journal, 50 (3), 640-643.


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