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Original Research 
RMJ. 2021; 46(3): 554-559


Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko.

Abstract
Objective: To evaluate the effects of the antiemetic drugs palonosetron and ramosetron, mixed with opioid-based intravenous patient-controlled analgesia (IV-PCA) regimen on postoperative nausea and vomiting (PONV).
Methodology: Patients were randomly allocated to three groups. Palonosetron (0.075 mg) was administered intravenously to all patients before anesthetic induction, and a 100-ml IV-PCA infusion, which contained 20 mcg/kg of fentanyl with placebo (normal saline) in group 1, ramosetron (0.3 mg) in group 2, and palonosetron (0.075 mg) in group 3 was started at the end of surgery. PONV, postoperative pain, and adverse effects were assessed.
Results: The incidence of postoperative nausea at PACU was lower in group 2 than in group 1 (5.6% vs 33.3%, p<0.05). Postoperative nausea scores at PACU and 6 h after discharge from PACU were significantly lower in group 2 and group 3 than in group 1. The requirement of rescue antiemetics was higher in group 1 than in other groups (p=0.004). There were no differences in the incidence and severity of PONV between ramosetron and palonosetron groups.
Conclusion: Infusion of palonosetron or ramosetron with the IV-PCA regimen may help to prevent PONV effectively. However, there was no difference between the effect of palonosetron and ramosetron.

Key words: 5-HT3 receptor antagonist, opioid, intravenous patient-controlled analgesia.


 
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How to Cite this Article
Pubmed Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . RMJ. 2021; 46(3): 554-559.


Web Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . http://www.rmj.org.pk/?mno=109045 [Access: August 11, 2021].


AMA (American Medical Association) Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . RMJ. 2021; 46(3): 554-559.



Vancouver/ICMJE Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . RMJ. (2021), [cited August 11, 2021]; 46(3): 554-559.



Harvard Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko (2021) Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . RMJ, 46 (3), 554-559.



Turabian Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. 2021. Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . Rawal Medical Journal, 46 (3), 554-559.



Chicago Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. "Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting ." Rawal Medical Journal 46 (2021), 554-559.



MLA (The Modern Language Association) Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko. "Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting ." Rawal Medical Journal 46.3 (2021), 554-559. Print.



APA (American Psychological Association) Style

Yei Heum Park, Yukyung Jeon, Jae-Wook Jung, Hyojoong Kim, Daeseok Oh, Myoung Jin Ko (2021) Effects of palonosetron and ramosetron mixed with intravenous patient-controlled analgesia infusion fluid after preoperative single injection of palonosetron for the prevention of postoperative nausea and vomiting . Rawal Medical Journal, 46 (3), 554-559.








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