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Original Research 
RMJ. 2022; 47(3): 764-767


Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats

Sidra Arshad, Mahvash Khan, Hira Ayaz, Anjum Syed, Ghazala Jawwad, Nasar Abbas Shamsi.

Abstract
Objective: To explore the role of dyslipidemia in development of thyroid disorder in type two diabetes mellitus.
Methodology: In this randomized control trial, 60 Sprague Dawley rats were divided into two groups with 30 rats in each group. Group 1 (control group) was fed on normal pellet diet and water whereas group two (diabetic group) was fed high fat diet to produce insulin resistance. After 2 weeks, an intra-peritoneal injection of normal saline was given to all the rats in-group 1, and group 2 rats were given single intra-peritoneal injection of Streptozocin (35 mg/kg) to produce hyperglycemia. At the end of study period (8 weeks), serum lipid profile, triiodothyronine, thyroxine and thyroid stimulating hormone levels were measured. Pearson correlation coefficient was calculated to find correlation between lipid profile and thyroid profile.
Results: There was no significant correlation of thyroid stimulating hormone, triiodothyronine and thyroxine with the parameters of lipid profile.
Conclusion: The deranged lipid profile had no role in disturbing the thyroid hormone levels in STZ induced type 2 diabetic Sprague Dawley rats.

Key words: Type 2 diabetes mellitus, thyroid dysfunctions, dyslipidemia.


 
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How to Cite this Article
Pubmed Style

Arshad S, Khan M, Ayaz H, Syed A, Jawwad G, Shamsi NA. Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. RMJ. 2022; 47(3): 764-767.


Web Style

Arshad S, Khan M, Ayaz H, Syed A, Jawwad G, Shamsi NA. Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. https://www.rmj.org.pk/?mno=102840 [Access: September 02, 2022].


AMA (American Medical Association) Style

Arshad S, Khan M, Ayaz H, Syed A, Jawwad G, Shamsi NA. Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. RMJ. 2022; 47(3): 764-767.



Vancouver/ICMJE Style

Arshad S, Khan M, Ayaz H, Syed A, Jawwad G, Shamsi NA. Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. RMJ. (2022), [cited September 02, 2022]; 47(3): 764-767.



Harvard Style

Arshad, S., Khan, . M., Ayaz, . H., Syed, . A., Jawwad, . G. & Shamsi, . N. A. (2022) Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. RMJ, 47 (3), 764-767.



Turabian Style

Arshad, Sidra, Mahvash Khan, Hira Ayaz, Anjum Syed, Ghazala Jawwad, and Nasar Abbas Shamsi. 2022. Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. Rawal Medical Journal, 47 (3), 764-767.



Chicago Style

Arshad, Sidra, Mahvash Khan, Hira Ayaz, Anjum Syed, Ghazala Jawwad, and Nasar Abbas Shamsi. "Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats." Rawal Medical Journal 47 (2022), 764-767.



MLA (The Modern Language Association) Style

Arshad, Sidra, Mahvash Khan, Hira Ayaz, Anjum Syed, Ghazala Jawwad, and Nasar Abbas Shamsi. "Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats." Rawal Medical Journal 47.3 (2022), 764-767. Print.



APA (American Psychological Association) Style

Arshad, S., Khan, . M., Ayaz, . H., Syed, . A., Jawwad, . G. & Shamsi, . N. A. (2022) Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats. Rawal Medical Journal, 47 (3), 764-767.








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