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RMJ. 2019; 44(4): 871-874


Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.

Arham Javed, Maira Mahmood, Uzma Jabbar , Muhammad Waqas Rabbani, Faiza Aamer, Farah Niazi, Riffat Yasmin .

Abstract
Objectives: To find the role of urinary retinol binding protein 4 (RBP-4) compared to serum creatinine, as a better predictors of impaired renal function in patients with type 2 diabetes.
Methodology: In this cross sectional study, 60 patients with T2D and 20 controls were included. Age of patients was in the range of 35-60 years with duration of diabetes <5.0 years. After an overnight fast, 5 ml blood was taken for analyses of fasting blood glucose, random blood glucose, glycated hemoglobin, blood urea nitrogen and serum creatinine. Their urine sample was also collected for estimation of urinary RBP-4. Estimation of fasting blood glucose, random blood glucose, glycated hemoglobin, blood urea nitrogen and serum creatinine was carried out by using standard kit read by autoanalyzer. Level of urinary RBP 4 was estimated by ELISA technique.
Results: It is observed that the level of fasting blood sugar, random blood sugar and HBA1c was significantly (P<0.001) increased in patients as compared to control subjects. Comparison of renal function in cases and controls showed that the levels of BUN, serum creatinine and of urinary RBP-4 was increased in patients as compared to controls but significant difference (P<0.001) was only observed in case of urinary RBP-4.
Conclusion: Urinary RBP-4 is an early indicator of renal impairment than serum creatinine in patients with type 2 diabetes. Estimation of RBP-4 may help to prevent renal failure in patients with DM.

Key words: Diabetic nephropathy, urinary RBP-4, serum creatinine.


 
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How to Cite this Article
Pubmed Style

Javed A, Mahmood M, UJ, Rabbani MW, Aamer F, Niazi F, RY, . Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. RMJ. 2019; 44(4): 871-874.


Web Style

Javed A, Mahmood M, UJ, Rabbani MW, Aamer F, Niazi F, RY, . Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. http://www.rmj.org.pk/?mno=43829 [Access: March 29, 2020].


AMA (American Medical Association) Style

Javed A, Mahmood M, UJ, Rabbani MW, Aamer F, Niazi F, RY, . Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. RMJ. 2019; 44(4): 871-874.



Vancouver/ICMJE Style

Javed A, Mahmood M, UJ, Rabbani MW, Aamer F, Niazi F, RY, . Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. RMJ. (2019), [cited March 29, 2020]; 44(4): 871-874.



Harvard Style

Javed, A. . ., Mahmood, M., , U. J., Rabbani, M. W., Aamer, F., Niazi, F., , R. Y. & (2019) Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. RMJ, 44 (4), 871-874.



Turabian Style

Javed, Arham , Maira Mahmood, Uzma Jabbar, Muhammad Waqas Rabbani, Faiza Aamer, Farah Niazi, Riffat Yasmin, and . 2019. Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. Rawal Medical Journal, 44 (4), 871-874.



Chicago Style

Javed, Arham , Maira Mahmood, Uzma Jabbar, Muhammad Waqas Rabbani, Faiza Aamer, Farah Niazi, Riffat Yasmin, and . "Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.." Rawal Medical Journal 44 (2019), 871-874.



MLA (The Modern Language Association) Style

Javed, Arham , Maira Mahmood, Uzma Jabbar, Muhammad Waqas Rabbani, Faiza Aamer, Farah Niazi, Riffat Yasmin, and . "Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.." Rawal Medical Journal 44.4 (2019), 871-874. Print.



APA (American Psychological Association) Style

Javed, A. . ., Mahmood, M., , U. J., Rabbani, M. W., Aamer, F., Niazi, F., , R. Y. & (2019) Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.. Rawal Medical Journal, 44 (4), 871-874.








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