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Review Article 
RMJ. 2019; 44(4): 875-879


Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem.

Abstract
Polycystic ovary syndrome (PCOS) is consider as the most common endocrine disorder in women of reproductive age. Strong evidence for a link between the follistatin gene and PCOS has been found in different studies. Follistatin binds to activin and affects its functions, secretion, and stimulation of FSH synthesis (follicle-stimulating hormone). It plays an important role in the functional impairment of the FSH-granulosa cell axis in PCOS. Gene implicated in ovarian follicular development may have a role in the etiology of PCOS, as demonstrated by the identification of the follistatin gene as a potential disease locus. It seems unlikely that PCOS can be explained based on single-gene disorder. One gene may have a predominant effect. Follistatin has been reported as a candidate gene for PCOS for linkage and associated studies. The objective of this review is to define the linkage between PCOS and the follistatin gene and the diagnostic value of PCOS.

Key words: Mutation, Follistatin gene, polycystic ovary syndrome, Hyperandrogonism.


 
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How to Cite this Article
Pubmed Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. RMJ. 2019; 44(4): 875-879.


Web Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. http://www.rmj.org.pk/?mno=294448 [Access: January 26, 2020].


AMA (American Medical Association) Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. RMJ. 2019; 44(4): 875-879.



Vancouver/ICMJE Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. RMJ. (2019), [cited January 26, 2020]; 44(4): 875-879.



Harvard Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem (2019) Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. RMJ, 44 (4), 875-879.



Turabian Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. 2019. Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. Rawal Medical Journal, 44 (4), 875-879.



Chicago Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. "Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome." Rawal Medical Journal 44 (2019), 875-879.



MLA (The Modern Language Association) Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem. "Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome." Rawal Medical Journal 44.4 (2019), 875-879. Print.



APA (American Psychological Association) Style

Sadia Zia, Maham Mushtaq, Mushtaq Ahmed Saleem (2019) Diagnostic value of follistatin gene mutations in women with polycystic ovary syndrome. Rawal Medical Journal, 44 (4), 875-879.








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