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Original Research Open Access
RMJ. 2017; 42(3): 366-371


Are all nasal polyps the same?

Salina Husain, Suria Hayati Mat Pauzi, Aneeza Khairiyah Wan Hamizan, Balwant Singh Gendeh, Valerie J Lund.

Abstract
Objective: To determine the pattern of cellular infiltration of Nasal Polyps (NP) in different Malaysian ethnic groups who co-exist within the same environment.
Methodology: A total of 176 patients with CRS with nasal polyposis (CRSwNP) were included in the study. Disease severity was measured by endoscopic examination and computed tomography (CT) using Lund-Mackay scoring system. The number of eosinophils and non-eosinophils were counted, and average number of inflammatory cells for each high power field was calculated.
Results: Eosinophil-predominant CRSwNP was seen in 35.8% of patients and 64.2% had non-eosinophil-predominant CRSwNP. Non-eosinophil predominant subtypes could be divided into neutrophil (31.3%), plasma cells and others (33%). Phenotypes of CRSwNP showed a significant association with ethnicity (x = 9.640; p < 0.05). 72% of nasal polyps in Chinese showed non-eosinophil predominance, while nasal polyps in Malays and Indians revealed 69% and 41% of the non-eosinophilic phenotype, respectively. However, no association was demonstrated between phenotype of CRSwNP and recurrence rate for NP, endoscopic staging (bilateral) or CT scores (p > 0.05).
Conclusion: Our study showed Malaysian Chinese and Malay ethnic groups had a non-eosinophilic phenotype of nasal polyps. This was particularly the case in the Malaysian Chinese population.

Key words: Chronic rhinosinusitis, nasal polyps, eosinophil, neutrophil, plasma cells.


 
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How to Cite this Article
Pubmed Style

Husain S, Pauzi SHM, Hamizan AKW, Gendeh BS, Lund VJ. Are all nasal polyps the same?. RMJ. 2017; 42(3): 366-371.



Web Style

Husain S, Pauzi SHM, Hamizan AKW, Gendeh BS, Lund VJ. Are all nasal polyps the same?. www.scopemed.org/?mno=273044 [Access: October 20, 2017].



AMA (American Medical Association) Style

Husain S, Pauzi SHM, Hamizan AKW, Gendeh BS, Lund VJ. Are all nasal polyps the same?. RMJ. 2017; 42(3): 366-371.



Vancouver/ICMJE Style

Husain S, Pauzi SHM, Hamizan AKW, Gendeh BS, Lund VJ. Are all nasal polyps the same?. RMJ. (2017), [cited October 20, 2017]; 42(3): 366-371.



Harvard Style

Husain, S., Pauzi, S. H. M., Hamizan, A. K. W., Gendeh, B. S. & Lund, V. J. (2017) Are all nasal polyps the same?. RMJ, 42 (3), 366-371.



Turabian Style

Husain, Salina, Suria Hayati Mat Pauzi, Aneeza Khairiyah Wan Hamizan, Balwant Singh Gendeh, and Valerie J Lund. 2017. Are all nasal polyps the same?. Rawal Medical Journal, 42 (3), 366-371.



Chicago Style

Husain, Salina, Suria Hayati Mat Pauzi, Aneeza Khairiyah Wan Hamizan, Balwant Singh Gendeh, and Valerie J Lund. "Are all nasal polyps the same?." Rawal Medical Journal 42 (2017), 366-371.



MLA (The Modern Language Association) Style

Husain, Salina, Suria Hayati Mat Pauzi, Aneeza Khairiyah Wan Hamizan, Balwant Singh Gendeh, and Valerie J Lund. "Are all nasal polyps the same?." Rawal Medical Journal 42.3 (2017), 366-371. Print.



APA (American Psychological Association) Style

Husain, S., Pauzi, S. H. M., Hamizan, A. K. W., Gendeh, B. S. & Lund, V. J. (2017) Are all nasal polyps the same?. Rawal Medical Journal, 42 (3), 366-371.




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