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Original Research Open Access
RMJ. 2017; 42(3): 286-290


Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women

Sumbal Zahid, Mumayyiza Tahir, Sameen Ahmed.

Abstract
Objective: To investigate the association of Vitamin D receptor (VDR) gene polymorphisms and development of osteoporosis.
Methodology: This case-control study was conducted at Sir Ganga Hospital and Sheikh Zayed Hospital, Lahore, Pakistan from January 2015 to August 2015. A total of 136 postmenopausal women between 46-75 years of age were included in the study while women with serious internal disease and premature (surgical) menopause before the age of 45 years were excluded. Genotyping of VDR ApaI, TaqI and BsmI loci was done using polymerase chain reaction-restriction fragment length polymorphism. Levels of ionized calcium, C-reactive protein, alkaline phosphatase were measured and body mass index was calculated. Statistical analysis was done by using SPSS version 16.0.
Results: Percentage of AA genotype was higher (28%) as compared to controls (16.6%). The postmenopausal cases showed 54% TT, 42%Tt and 4% tt genotype. The Bb genotype (42.6 %) was most frequent in both cases and controls. Postmenopausal cases and controls showed non-significant difference in alkaline phosphatase, C-reactive protein and ionized calcium levels.
Conclusions: Findings explained the earlier inconsistent association results and no particular genetic variation in Vitamin D receptor gene had pronounced effect in predisposition to osteoporosis.

Key words: Osteoporosis, postmenopausal women, vitamin D receptor gene polymorphisms


 
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Pubmed Style

Zahid S, Tahir M, Ahmed S. Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. RMJ. 2017; 42(3): 286-290.


Web Style

Zahid S, Tahir M, Ahmed S. Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. http://www.rmj.org.pk/?mno=258824 [Access: December 17, 2017].


AMA (American Medical Association) Style

Zahid S, Tahir M, Ahmed S. Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. RMJ. 2017; 42(3): 286-290.



Vancouver/ICMJE Style

Zahid S, Tahir M, Ahmed S. Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. RMJ. (2017), [cited December 17, 2017]; 42(3): 286-290.



Harvard Style

Zahid, S., Tahir, M. & Ahmed, S. (2017) Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. RMJ, 42 (3), 286-290.



Turabian Style

Zahid, Sumbal, Mumayyiza Tahir, and Sameen Ahmed. 2017. Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. Rawal Medical Journal, 42 (3), 286-290.



Chicago Style

Zahid, Sumbal, Mumayyiza Tahir, and Sameen Ahmed. "Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women." Rawal Medical Journal 42 (2017), 286-290.



MLA (The Modern Language Association) Style

Zahid, Sumbal, Mumayyiza Tahir, and Sameen Ahmed. "Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women." Rawal Medical Journal 42.3 (2017), 286-290. Print.



APA (American Psychological Association) Style

Zahid, S., Tahir, M. & Ahmed, S. (2017) Molecular genetic variations in vitamin D receptor gene with risk of osteoporosis in postmenopausal women. Rawal Medical Journal, 42 (3), 286-290.




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