Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Research 
RMJ. 2019; 44(3): 472-476


Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma

Shifa Basharat, Bibi Hasina Iqtidar, Shaleem Naeem, Zufishan Batool, Nosheen Ali, Zahra Ahmad.

Abstract
Objective: To determine the clinicopathological and immunohistochemical patterns of non-Hodgkin lymphoma (NHL) at our institution.
Methodology: This descriptive study was conducted in the pathology department, Rehman Medical Institute, Peshawar from July 2013 to Jan 2018. Total 139 proven cases of NHL were included. The antibodies used were LCA, CD 20, CD3, CD30, CD15, Ki-67, CD10, CD5, Cyclin D1, Bcl-2, CD23, CD43. SPSS version 23 was used to analyze data. Chi-square test was applied and a p< 0.05 was taken as significant.
Results: Out of 139 patients, 96(69.1%) were male and 43(30.9%) female, most in the age group 51-60 years. The mean age was 46.04 ±21.06 years (range 2-102). Male: female ratio was 2.21:1. The most common presenting feature was neck swelling (41.72%). Primary site distribution was nodal (35.25%) and extra‑nodal (64.74%). The most common involved lymph node sites were cervical lymph (69.38%), and extra‑nodal NHL included majority cases bone marrow involvement (55%). B-cell lymphomas formed 90.64%, whereas T-cell lymphomas formed 9.36%. In B cell lymphoma, 20.63% was DLBCL, and majority of T‑cell lymphoma were extra-nodal NK and Precursor T-cell lymphoblastic lymphoma, noted in 38% each.
Conclusion: Most common lymphoma was B-cell lymphoma, in which DLBCL was on the top. In T-Cell Lymphoma, extra-nodal NK was the most common. Immunohistochemistry is an important investigation for all lymphomas, which is vital for immunotherapy and for differential diagnosis with other malignancies.

Key words: Non-Hodgkin lymphoma, lymph nodes, DLBCL.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shifa Basharat
Articles by Bibi Hasina Iqtidar
Articles by Shaleem Naeem
Articles by Zufishan Batool
Articles by Nosheen Ali
Articles by Zahra Ahmad
on Google
on Google Scholar
Article Statistics
 Viewed: 929
Downloaded: 5
Cited: 0


How to Cite this Article
Pubmed Style

Basharat S, Iqtidar BH, Naeem S, Batool Z, Ali N, Ahmad Z. Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. RMJ. 2019; 44(3): 472-476.


Web Style

Basharat S, Iqtidar BH, Naeem S, Batool Z, Ali N, Ahmad Z. Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. http://www.rmj.org.pk/?mno=16161 [Access: August 23, 2019].


AMA (American Medical Association) Style

Basharat S, Iqtidar BH, Naeem S, Batool Z, Ali N, Ahmad Z. Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. RMJ. 2019; 44(3): 472-476.



Vancouver/ICMJE Style

Basharat S, Iqtidar BH, Naeem S, Batool Z, Ali N, Ahmad Z. Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. RMJ. (2019), [cited August 23, 2019]; 44(3): 472-476.



Harvard Style

Basharat, S., Iqtidar, . B. H., Naeem, . S., Batool, . Z., Ali, . N. & Ahmad, . Z. (2019) Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. RMJ, 44 (3), 472-476.



Turabian Style

Basharat, Shifa, Bibi Hasina Iqtidar, Shaleem Naeem, Zufishan Batool, Nosheen Ali, and Zahra Ahmad. 2019. Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. Rawal Medical Journal, 44 (3), 472-476.



Chicago Style

Basharat, Shifa, Bibi Hasina Iqtidar, Shaleem Naeem, Zufishan Batool, Nosheen Ali, and Zahra Ahmad. "Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma." Rawal Medical Journal 44 (2019), 472-476.



MLA (The Modern Language Association) Style

Basharat, Shifa, Bibi Hasina Iqtidar, Shaleem Naeem, Zufishan Batool, Nosheen Ali, and Zahra Ahmad. "Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma." Rawal Medical Journal 44.3 (2019), 472-476. Print.



APA (American Psychological Association) Style

Basharat, S., Iqtidar, . B. H., Naeem, . S., Batool, . Z., Ali, . N. & Ahmad, . Z. (2019) Clinicopathological and immunohistochemical profile of patients with Non-hodgkin’s lymphoma. Rawal Medical Journal, 44 (3), 472-476.








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Indexed in WHO Index Medicus IMEMR, Emromedex, Pakmedinet, ExtraMED and Scopus

  Approved by the Higher Education Commission of Pakistan and Pakistan Medical and Dental Council


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Rawal Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.