ISSN 0303-5212
 
2024, Vol: 49, Issue: 2
49 / 2Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_ Certificate.docx
Bank Reciept

Original Research 
RMJ. 2023; 48(4): 839-842


Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease

Muhammad Sajid Mehmood, Wajahat Sultan Baig, Tehreem Aftab, Umar Kaleem, Muhammad Hammad, Shazia Siddiq.

Abstract
Objective: To compare efficacy of febuxostat 40mg daily with febuxostat 80 mg daily in treating hyperuricemia in patients with chronic kidney disease.
Methodology: This comparative multi-centric study was done from 01-01-2018 to 30-06-2018 on 305 patients of chronic renal failure (S. Creatinine 2.1±0.35) and raised serum uric acid levels were included in the study. It was non-probability consecutive sampling. The patients were in range of 18 to 70 years. They were not on dialysis. A total of 151 patients were given febuxostat 40mg OD and 147 were treated with febuxostat 80mg OD for 4 weeks. Serum uric acid levels of more than 7.0mmol/l in males and 6.0mg/dl in females was labelled as hyperuricemia. Serum uric acid levels were estimated at beginning and end of 4 weeks of treatment. Chi-square test was used for comparison between two groups.
Results: The serum uric acid levels decreased in 68.1% of patients. In febuxostat 80mg OD group, 76.2% patients responded to treatment while in febuxostat 40mg OD group 59.2% achieved target uric acid levels (p=0.025).
Conclusion: Febuxostat 80 mg treated hyperuricemia more effectively than febuxostat 40 mg and did not deteriorate renal functioning.

Key words: Chronic kidney disease, hyperuricemia, efficacy, xanthine oxidase inhibitor, renal insufficiency, febuxostat.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Muhammad Sajid Mehmood
Articles by Wajahat Sultan Baig
Articles by Tehreem Aftab
Articles by Umar Kaleem
Articles by Muhammad Hammad
Articles by Shazia Siddiq
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Mehmood MS, Baig WS, Aftab T, Kaleem U, Hammad M, Siddiq S. Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. RMJ. 2023; 48(4): 839-842.

Web Style

Mehmood MS, Baig WS, Aftab T, Kaleem U, Hammad M, Siddiq S. Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. https://www.rmj.org.pk/?mno=50458 [Access: December 04, 2023].

AMA (American Medical Association) Style

Mehmood MS, Baig WS, Aftab T, Kaleem U, Hammad M, Siddiq S. Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. RMJ. 2023; 48(4): 839-842.


Vancouver/ICMJE Style

Mehmood MS, Baig WS, Aftab T, Kaleem U, Hammad M, Siddiq S. Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. RMJ. (2023), [cited December 04, 2023]; 48(4): 839-842.


Harvard Style

Mehmood, M. S., Baig, . W. S., Aftab, . T., Kaleem, . U., Hammad, . M. & Siddiq, . S. (2023) Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. RMJ, 48 (4), 839-842.


Turabian Style

Mehmood, Muhammad Sajid, Wajahat Sultan Baig, Tehreem Aftab, Umar Kaleem, Muhammad Hammad, and Shazia Siddiq. 2023. Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. Rawal Medical Journal, 48 (4), 839-842.


Chicago Style

Mehmood, Muhammad Sajid, Wajahat Sultan Baig, Tehreem Aftab, Umar Kaleem, Muhammad Hammad, and Shazia Siddiq. "Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease." Rawal Medical Journal 48 (2023), 839-842.


MLA (The Modern Language Association) Style

Mehmood, Muhammad Sajid, Wajahat Sultan Baig, Tehreem Aftab, Umar Kaleem, Muhammad Hammad, and Shazia Siddiq. "Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease." Rawal Medical Journal 48.4 (2023), 839-842. Print.


APA (American Psychological Association) Style

Mehmood, M. S., Baig, . W. S., Aftab, . T., Kaleem, . U., Hammad, . M. & Siddiq, . S. (2023) Efficacy of 40 mg vs. 80mg daily doses of febuxostat in treating hyperuricemia in chronic kidney disease. Rawal Medical Journal, 48 (4), 839-842.


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information