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Original Research 
RMJ. 2019; 44(2): 330-333


Association of carcinoembryonic antigen levels with site and stage of colorectal tumor

Amjad Siraj Memon, Naveed Ali Khan, Khursheed A Samo, Ata-Ur Rehman, Iqra Khan, Sara Khan.

Abstract
Objective: To determine the association of carcinoembryonic antigen (CEA) levels in colorectal cancer with regard to the site and the stage of the tumor.
Methodology: This cross-sectional study was conducted in Surgical unit 3, colorectal ward, Civil Hospital, Karachi, from January 2010 to June 2015. CEA level was monitored in all patient admitted to the unit. Normal pre-operative serum levels for CEA in of patients with colorectal carcinoma were considered <2.5 ng/mL for non-smokers and <5.0 ng/mL for smokers. Any patient above this level was labeled as CEA positive case.
Results: Out of 310 biopsy-proven patients, only 228 (73.6%) were found to have elevated CEA level at the time of diagnosis. The majority (72%) of the patient had adenocarcinoma and 83.4% were CEA positive. CEA positive cases with sigmoid colon was found significantly higher (86.8%) followed by rectum (79.5%) and descending colon (68.4%) (p<0.001). CEA positive cases were significantly higher in Dukes stage D and C, 88.5% and 86.02%, respectively (p<0.001).
Conclusion: Patients with positive CEA levels were found to be associated more in the sigmoid colon and rectal carcinoma. While the DUKE D stage was associated with maximum positive cases of CEA levels.

Key words: CEA levels, colorectal cancer, site of tumor, stage of the tumor.


 
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How to Cite this Article
Pubmed Style

Memon AS, Khan NA, Samo KA, Rehman A, Khan I, Khan S. Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. RMJ. 2019; 44(2): 330-333.


Web Style

Memon AS, Khan NA, Samo KA, Rehman A, Khan I, Khan S. Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. http://www.rmj.org.pk/?mno=289617 [Access: August 25, 2019].


AMA (American Medical Association) Style

Memon AS, Khan NA, Samo KA, Rehman A, Khan I, Khan S. Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. RMJ. 2019; 44(2): 330-333.



Vancouver/ICMJE Style

Memon AS, Khan NA, Samo KA, Rehman A, Khan I, Khan S. Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. RMJ. (2019), [cited August 25, 2019]; 44(2): 330-333.



Harvard Style

Memon, A. S., Khan, . N. A., Samo, . K. A., Rehman, . A., Khan, . I. & Khan, . S. (2019) Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. RMJ, 44 (2), 330-333.



Turabian Style

Memon, Amjad Siraj, Naveed Ali Khan, Khursheed A Samo, Ata-Ur Rehman, Iqra Khan, and Sara Khan. 2019. Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. Rawal Medical Journal, 44 (2), 330-333.



Chicago Style

Memon, Amjad Siraj, Naveed Ali Khan, Khursheed A Samo, Ata-Ur Rehman, Iqra Khan, and Sara Khan. "Association of carcinoembryonic antigen levels with site and stage of colorectal tumor." Rawal Medical Journal 44 (2019), 330-333.



MLA (The Modern Language Association) Style

Memon, Amjad Siraj, Naveed Ali Khan, Khursheed A Samo, Ata-Ur Rehman, Iqra Khan, and Sara Khan. "Association of carcinoembryonic antigen levels with site and stage of colorectal tumor." Rawal Medical Journal 44.2 (2019), 330-333. Print.



APA (American Psychological Association) Style

Memon, A. S., Khan, . N. A., Samo, . K. A., Rehman, . A., Khan, . I. & Khan, . S. (2019) Association of carcinoembryonic antigen levels with site and stage of colorectal tumor. Rawal Medical Journal, 44 (2), 330-333.








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